l -Glutamate-induced responses in OFF-type bipolar cells of the cat retina

l -Glutamate-induced responses in OFF-type bipolar cells of the cat retina l -Glutamate (Glu)-induced current responses were studied in 119 isolated OFF-type bipolar cells of the cat retina. Cells were recorded by the patch clamp technique in the whole-cell configuration. Glu induced a current carried by alkali metal ions and divalent cations with a permeability ratio of P Na :P K :P Cs :P Ca = 1:0.94:1.32:0.57. Sensitivity to Glu was highest in the dendritic region. Kainate and AMPA worked as potent agonist, but neither APB, l -aspartate, ACPD, nor NMDA (all at 100 μM) was effective. The Glu-induced response was antagonized by > 1 μM CNQX. We inferred that OFF-type bipolar cells have a non-NMDA receptor channel that is permeable to alkali metal ions with low selectivity, but not NMDA receptor or metabotropic Glu receptor. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Vision Research Elsevier

l -Glutamate-induced responses in OFF-type bipolar cells of the cat retina

Vision Research, Volume 36 (6) – Mar 1, 1996

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Publisher
Elsevier
Copyright
Copyright © 1996 Elsevier Science Ltd
ISSN
0042-6989
eISSN
1878-5646
D.O.I.
10.1016/0042-6989(95)00176-X
Publisher site
See Article on Publisher Site

Abstract

l -Glutamate (Glu)-induced current responses were studied in 119 isolated OFF-type bipolar cells of the cat retina. Cells were recorded by the patch clamp technique in the whole-cell configuration. Glu induced a current carried by alkali metal ions and divalent cations with a permeability ratio of P Na :P K :P Cs :P Ca = 1:0.94:1.32:0.57. Sensitivity to Glu was highest in the dendritic region. Kainate and AMPA worked as potent agonist, but neither APB, l -aspartate, ACPD, nor NMDA (all at 100 μM) was effective. The Glu-induced response was antagonized by > 1 μM CNQX. We inferred that OFF-type bipolar cells have a non-NMDA receptor channel that is permeable to alkali metal ions with low selectivity, but not NMDA receptor or metabotropic Glu receptor.

Journal

Vision ResearchElsevier

Published: Mar 1, 1996

References

  • Neurotransmitter-induced currents in retinal bipolar cells of the axolotl, Ambystoma mexicanum
    Attwell, D.; Mobbs, P.; Tessier-Lavigne, M.; Wilson, M.
  • Cloned glutamate receptors
    Hollmann, M.; Heinemann, S.
  • Physiological and morphological identification of horizontal, bipolar and amacrine cells in goldfish retina
    Kaneko, A.
  • Horizontal cells isolated from catfish retina contain two types of excitatory amino acid receptors
    O'Dell, T.J.; Christensen, B.N.
  • Permeability changes produced by l -glutamate at the excitatory post-synaptic membrane of the crayfish muscle
    Onodera, K.; Takeuchi, A.
  • Effects of glycine and GABA on isolated bipolar cells of the mouse retina
    Suzuki, S.; Tachibana, M.; Kaneko, A.

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