l -Glutamate (Glu)-induced current responses were studied in 119 isolated OFF-type bipolar cells of the cat retina. Cells were recorded by the patch clamp technique in the whole-cell configuration. Glu induced a current carried by alkali metal ions and divalent cations with a permeability ratio of P Na :P K :P Cs :P Ca = 1:0.94:1.32:0.57. Sensitivity to Glu was highest in the dendritic region. Kainate and AMPA worked as potent agonist, but neither APB, l -aspartate, ACPD, nor NMDA (all at 100 μM) was effective. The Glu-induced response was antagonized by > 1 μM CNQX. We inferred that OFF-type bipolar cells have a non-NMDA receptor channel that is permeable to alkali metal ions with low selectivity, but not NMDA receptor or metabotropic Glu receptor.
Vision Research – Elsevier
Published: Mar 1, 1996
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