Ketanserin attenuates the behavioural effects of corticosterone: implications for 5-HT 2A receptor regulation

Ketanserin attenuates the behavioural effects of corticosterone: implications for 5-HT 2A... The effects of chronic corticosterone treatment on sexual behaviour and wet-dog shakes were investigated in both female and male rats. The serotonergic type 2A (5-HT 2A ) receptor antagonist ketanserin was administered to test the hypothesis that the behavioural effects of corticosterone were mediated by increased 5-HT 2A receptor activity. Rats were randomly assigned to one of four chronic treatment groups: control, ketanserin alone, corticosterone alone, or ketanserin and corticosterone. Ketanserin attenuated the corticosterone-induced changes in both sexual behaviour and wet-dog shakes. Ketanserin alone had no effect on these behaviours. Results suggest that increased 5-HT 2A receptor activity mediates the effects of corticosterone on sexual behaviour and wet-dog shakes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Ketanserin attenuates the behavioural effects of corticosterone: implications for 5-HT 2A receptor regulation

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science B.V.
ISSN
0014-2999
D.O.I.
10.1016/S0014-2999(01)01353-X
Publisher site
See Article on Publisher Site

Abstract

The effects of chronic corticosterone treatment on sexual behaviour and wet-dog shakes were investigated in both female and male rats. The serotonergic type 2A (5-HT 2A ) receptor antagonist ketanserin was administered to test the hypothesis that the behavioural effects of corticosterone were mediated by increased 5-HT 2A receptor activity. Rats were randomly assigned to one of four chronic treatment groups: control, ketanserin alone, corticosterone alone, or ketanserin and corticosterone. Ketanserin attenuated the corticosterone-induced changes in both sexual behaviour and wet-dog shakes. Ketanserin alone had no effect on these behaviours. Results suggest that increased 5-HT 2A receptor activity mediates the effects of corticosterone on sexual behaviour and wet-dog shakes.

Journal

European Journal of PharmacologyElsevier

Published: Oct 5, 2001

References

  • Modulation of 5-HT receptor subtype-mediated behaviours by corticosterone
    Berendsen, H.H.G.; Kester, R.C.H.; Peeters, B.W.M.M.; Broekkamp, C.L.E.
  • 5-HT 2 receptor characteristics in frontal cortex and 5-HT 2 receptor-mediated head twitch behaviour following antidepressant treatment to mice
    Goodwin, G.M.; Green, A.R.; Johnson, P.
  • Classification and nomenclature of 5-HT receptors: a comment on current issues
    Hoyer, D.; Martin, G.R.
  • The role of the aural head shake reflex in serotonin-mediated head shaking behavior
    Lucki, I.; Eberle, K.M.; Minugh-Purvis, N.

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