Japanese encephalitis virus induces apoptosis by inhibiting Foxo signaling pathway

Japanese encephalitis virus induces apoptosis by inhibiting Foxo signaling pathway •Foxo expression is reduced by JEV infection in vitro and in vivo.•Foxo inhibits JEV-induced apoptosis.•Foxo exerts an anti-apoptotic function by Bcl-6 and p21 during JEV infection.•JEV reduces Foxo expression, at least in part, by downregulating STAT3. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Veterinary Microbiology Elsevier

Japanese encephalitis virus induces apoptosis by inhibiting Foxo signaling pathway

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier B.V.
ISSN
0378-1135
eISSN
1873-2542
D.O.I.
10.1016/j.vetmic.2018.05.008
Publisher site
See Article on Publisher Site

Abstract

•Foxo expression is reduced by JEV infection in vitro and in vivo.•Foxo inhibits JEV-induced apoptosis.•Foxo exerts an anti-apoptotic function by Bcl-6 and p21 during JEV infection.•JEV reduces Foxo expression, at least in part, by downregulating STAT3.

Journal

Veterinary MicrobiologyElsevier

Published: Jul 1, 2018

References

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