Ischemia-induced neuronal apoptosis

Ischemia-induced neuronal apoptosis Hypoxic-ischemic neuronal death has long been considered to represent necrosis, but it now appears that many brain neuron sundergo apoptosis after either global or focal ischemic insults. This event is probably substantially distinct from ischemia-triggered excitotoxicity, which tends to produce necrosis. While many questions remain unanswered, the concept of ischemic apoptosis has raised exciting prospects of combining anti-apoptotic with anti-excitotoxic treatments to achieve heightened therapeutic benefits in the brains of patients traumatized by cardiac arrest or stroke. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Neurobiology Elsevier

Ischemia-induced neuronal apoptosis

Current Opinion in Neurobiology, Volume 6 (5) – Oct 1, 1996

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Publisher
Elsevier
Copyright
Copyright © 1996 Elsevier Ltd
ISSN
0959-4388
D.O.I.
10.1016/S0959-4388(96)80101-2
Publisher site
See Article on Publisher Site

Abstract

Hypoxic-ischemic neuronal death has long been considered to represent necrosis, but it now appears that many brain neuron sundergo apoptosis after either global or focal ischemic insults. This event is probably substantially distinct from ischemia-triggered excitotoxicity, which tends to produce necrosis. While many questions remain unanswered, the concept of ischemic apoptosis has raised exciting prospects of combining anti-apoptotic with anti-excitotoxic treatments to achieve heightened therapeutic benefits in the brains of patients traumatized by cardiac arrest or stroke.

Journal

Current Opinion in NeurobiologyElsevier

Published: Oct 1, 1996

References

  • Molecular mechanisms of developmental neuronal death
    Johnson, EM; Deckwerth, TL
  • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    Gavrieli, Y; Sherman, Y; Ben-Sasson, SA
  • Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis
    Chow, SC; Peters, I; Orrhenius, S
  • Cell death: the significance of apoptosis
    Wyllie, AH; Kerr, JFR; Currie, AR
  • Excitotoxic cell death
    Choi, DW
  • Delayed application of aurintricarboxylic acid reduces glutamate-induced cortical neuronal injury
    Csernansky, CA; Canzoniero, LMT; Sensi, S; Yu, SP; Choi, DW
  • Evidence for hypoxia-induced, programmed cell death of cultured neurons
    Rosenbaum, DM; Michaelson, M; Batter, DK; Doshi, P; Kessler, JA

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