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A review of iron and cadmium transport by renal tubules highlighting common pathways and differences with their implications for health and disease. 1. Introduction Until recently, the kidney was thought ...
Brilliant new discoveries in the field of iron metabolism have revealed novel transmembrane iron transporters , novel hormones that regulate iron traffic, and iron's control of gene expression ...
regulatory protein (IRE–IRP) system. In the kidney , iron transport mechanisms independent of the IRE–IRP system have been identified, suggesting additional mechanisms for iron handling in this organ. Yet ...
communities. Iron plays essential roles in many biological processes including oxygen transport , mitochondrial function, cell proliferation, and regeneration. However, excess iron induces the generation ...
of iron in the liver and kidney , reducing its transport to the brain. These observations provide direct evidence for the transport of NTBI to the brain, and reveal a complex interplay between inflammation ...
Iron is an essential trace element involved in oxidation–reduction reactions, oxygen transport and storage, and energy metabolism. Iron in excess can be toxic for cells, since iron produces reactive ...
No morphological kidney damage due to parenteral systemic iron overload To study how iron transport is regulated during PIO, we caused PIO in mice by injecting iron dextran into the peritoneum. Histological analysis ...
Ferroptosis is caused by lipid peroxidation and iron accumulation and can cause cell death. Abnormally expressed iron transporters are involved in ferroptosis in a variety of diseases. ZRT/IRT-like ...
Iron chelators are effective at removing iron from the body in iron overload, but little is known about the handling of iron chelates by the kidney . We studied the transport of deferoxamine ...
It is generally accepted that iron homeostasis is mainly controlled in the gastrointestinal tract by absorption of dietary iron . However, recent studies have shown that the kidneys are also involved ...
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