Carbohydrate Polymers 181 (2018) 345–350 Contents lists available at ScienceDirect Carbohydrate Polymers journal homepage: www.elsevier.com/locate/carbpol Research Paper Ion-crosslinked wood-derived nanocellulose hydrogels with tunable antibacterial properties: Candidate materials for advanced wound care applications ⁎ ⁎ Alex Basu, Karen Heitz, Maria Strømme, Ken Welch , Natalia Ferraz Nanotechnology and Functional Materials, Department of Engineering Sciences, Uppsala University, Box 534, 751 21 Uppsala, Sweden ARTICLE I NFO ABSTRACT Keywords: Development of advanced dressings with antimicrobial properties for the treatment of infected wounds is an Nanoﬁbrillated cellulose important approach in the ﬁght against evolution of antibiotic resistant bacterial strains. Herein, the eﬀects of Bioﬁlm ion-crosslinked nanocellulose hydrogels on bacteria commonly found in infected wounds were investigated in Wound dressing vitro. By using divalent calcium or copper ions as crosslinking agents, diﬀerent antibacterial properties against Infected wound the bacterial strains Staphylococcus epidermidis and Pseudomonas aeruginosa were obtained. Calcium crosslinked hydrogels were found to retard S. epidermidis growth (up to 266% increase in lag time, 36% increase in doubling time) and inhibited P. aeruginosa bioﬁlm formation, while copper crosslinked hydrogels prevented S. epidermidis growth and were bacteriostatic towards P. aeruginosa (49% increase in lag time, 78% increase in doubling time). The wound dressing candidates furthermore
Carbohydrate Polymers – Elsevier
Published: Feb 1, 2018
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