Involvement of serotonergic system in the antidepressant-like effect of piperine

Involvement of serotonergic system in the antidepressant-like effect of piperine Piperine is a major alkaloid of black pepper ( Piper nigrum Linn.) and long pepper ( P. longum Linn.), and its antidepressant-like effect has been previously demonstrated. The purpose of this study was to explore the possible contribution of the serotonergic system in the antidepressant-like effect of piperine in mice. The results showed that piperine significantly reduced the immobility time in the forced swim test and tail suspension test in mice. The anti-immobility effect of piperine in the forced swim test and tail suspension test was completely abolished by pre-treating the mice with pCPA (an inhibitor of 5-HT synthesis). Piperine treatment also significantly potentiated the number of head-twitches of mice induced by 5-HTP (a metabolic precursor to 5-HT). In addition, the neurochemical assays showed that piperine produced a marked increase of 5-HT level in both the hippocampus and frontal cortex of mice. Taken together, these results clearly suggest that the antidepressant-like effect of piperine is mediated via the serotonergic system by enhancing 5-HT content in mouse brain. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Progress in Neuro-Psychopharmacology & Biological Psychiatry Elsevier

Involvement of serotonergic system in the antidepressant-like effect of piperine

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Publisher
Elsevier
Copyright
Copyright © 2011 Elsevier Inc.
ISSN
0278-5846
eISSN
1878-4216
DOI
10.1016/j.pnpbp.2011.03.017
Publisher site
See Article on Publisher Site

Abstract

Piperine is a major alkaloid of black pepper ( Piper nigrum Linn.) and long pepper ( P. longum Linn.), and its antidepressant-like effect has been previously demonstrated. The purpose of this study was to explore the possible contribution of the serotonergic system in the antidepressant-like effect of piperine in mice. The results showed that piperine significantly reduced the immobility time in the forced swim test and tail suspension test in mice. The anti-immobility effect of piperine in the forced swim test and tail suspension test was completely abolished by pre-treating the mice with pCPA (an inhibitor of 5-HT synthesis). Piperine treatment also significantly potentiated the number of head-twitches of mice induced by 5-HTP (a metabolic precursor to 5-HT). In addition, the neurochemical assays showed that piperine produced a marked increase of 5-HT level in both the hippocampus and frontal cortex of mice. Taken together, these results clearly suggest that the antidepressant-like effect of piperine is mediated via the serotonergic system by enhancing 5-HT content in mouse brain.

Journal

Progress in Neuro-Psychopharmacology & Biological PsychiatryElsevier

Published: Jun 1, 2011

References

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