Introduction of diffusing wave spectroscopy to study self-emulsifying drug delivery systems with respect to liquid filling of capsules

Introduction of diffusing wave spectroscopy to study self-emulsifying drug delivery systems with... Article history: The rheology of self-emulsifying drug delivery systems (SEDDS) is not thoroughly characterized these Received 6 September 2011 days. Since mechanical rheometers are often not well suited to study this kind of systems, there is need Accepted 19 January 2012 for novel physical methods. Several new optical techniques based on microrheology have recently made Available online 30 January 2012 significant progress. We apply for the first time a specific microrheological technique called diffusing wave spectroscopy (DWS) to study different SEDDS. The obtained data were then correlated with the Keywords: dosing precision of automated capsule filling. Diffusing wave spectroscopy As a result, the dynamic viscosities obtained from microrheology were in accordance with data from Microrheology capillary viscosimetry. The DWS measurements revealed that all formulations had a clearly measur- Visco-elastic able storage modulus at frequencies >200 rad/s. Thus, all samples were low-viscous, while exhibiting Self-emulsifying drug delivery systems non-Newtonian flow behavior. Obtained values of storage and loss modulus were then successfully cor- Capsules Quality by design related with the weight variability of capsules that were filled on a machine. In conclusion, the DWS technique enabled rheological analysis of self-emulsifying systems in a broad frequency range. The good data correlation with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Pharmaceutics Elsevier

Introduction of diffusing wave spectroscopy to study self-emulsifying drug delivery systems with respect to liquid filling of capsules

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Publisher
Elsevier
Copyright
Copyright © 2012 Elsevier B.V.
ISSN
0378-5173
D.O.I.
10.1016/j.ijpharm.2012.01.042
Publisher site
See Article on Publisher Site

Abstract

Article history: The rheology of self-emulsifying drug delivery systems (SEDDS) is not thoroughly characterized these Received 6 September 2011 days. Since mechanical rheometers are often not well suited to study this kind of systems, there is need Accepted 19 January 2012 for novel physical methods. Several new optical techniques based on microrheology have recently made Available online 30 January 2012 significant progress. We apply for the first time a specific microrheological technique called diffusing wave spectroscopy (DWS) to study different SEDDS. The obtained data were then correlated with the Keywords: dosing precision of automated capsule filling. Diffusing wave spectroscopy As a result, the dynamic viscosities obtained from microrheology were in accordance with data from Microrheology capillary viscosimetry. The DWS measurements revealed that all formulations had a clearly measur- Visco-elastic able storage modulus at frequencies >200 rad/s. Thus, all samples were low-viscous, while exhibiting Self-emulsifying drug delivery systems non-Newtonian flow behavior. Obtained values of storage and loss modulus were then successfully cor- Capsules Quality by design related with the weight variability of capsules that were filled on a machine. In conclusion, the DWS technique enabled rheological analysis of self-emulsifying systems in a broad frequency range. The good data correlation with

Journal

International Journal of PharmaceuticsElsevier

Published: Apr 15, 2012

References

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