Article history: The rheology of self-emulsifying drug delivery systems (SEDDS) is not thoroughly characterized these Received 6 September 2011 days. Since mechanical rheometers are often not well suited to study this kind of systems, there is need Accepted 19 January 2012 for novel physical methods. Several new optical techniques based on microrheology have recently made Available online 30 January 2012 signiﬁcant progress. We apply for the ﬁrst time a speciﬁc microrheological technique called diffusing wave spectroscopy (DWS) to study different SEDDS. The obtained data were then correlated with the Keywords: dosing precision of automated capsule ﬁlling. Diffusing wave spectroscopy As a result, the dynamic viscosities obtained from microrheology were in accordance with data from Microrheology capillary viscosimetry. The DWS measurements revealed that all formulations had a clearly measur- Visco-elastic able storage modulus at frequencies >200 rad/s. Thus, all samples were low-viscous, while exhibiting Self-emulsifying drug delivery systems non-Newtonian ﬂow behavior. Obtained values of storage and loss modulus were then successfully cor- Capsules Quality by design related with the weight variability of capsules that were ﬁlled on a machine. In conclusion, the DWS technique enabled rheological analysis of self-emulsifying systems in a broad frequency range. The good data correlation with
International Journal of Pharmaceutics – Elsevier
Published: Apr 15, 2012
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