Intracytoplasmic sperm injection (ICSI) is a component of in vitro fertilization (IVF), a standard clinical technique for many years, and is no longer considered experimental. Several studies have demonstrated the efficacy and short-term safety of ICSI. It is utilized for the treatment of infertility due to a male factor or selected female factors including, but not limited to, morphologic anomalies of the oocyte, limited quantities of oocytes, and anomalies of the zona pellucida. In addition, ICSI may be needed for IVF treatment if polyspermy or poor fertilization occurred in a prior cycle where insemination alone was used or if preimplantation genetic diagnosis (PGD) is planned, especially for single gene defects. Approved by the Practice Committee of the American Society for Reproductive Medicine in 2006. Approved by the Board of Directors of the American Society for Reproductive Medicine in 2006.</P>
Fertility and Sterility – Elsevier
Published: Nov 1, 2008
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