Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C

Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B... Background & Aims The host immune response during the chronic phase of hepatitis C virus infection varies among individuals; some patients have a no interferon (IFN) response in the liver, whereas others have full activation of IFN-stimulated genes (ISGs). Preactivation of this endogenous IFN system is associated with nonresponse to pegylated IFN-α (pegIFN-α) and ribavirin. Genome-wide association studies have associated allelic variants near the IL28B ( IFNλ 3) gene with treatment response. We investigated whether IL28B genotype determines the constitutive expression of ISGs in the liver and compared the abilities of ISG levels and IL28B genotype to predict treatment outcome. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Gastroenterology Elsevier

Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C

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Publisher
Elsevier
Copyright
Copyright © 2011 AGA Institute
ISSN
0016-5085
eISSN
1528-0012
D.O.I.
10.1053/j.gastro.2010.11.039
Publisher site
See Article on Publisher Site

Abstract

Background & Aims The host immune response during the chronic phase of hepatitis C virus infection varies among individuals; some patients have a no interferon (IFN) response in the liver, whereas others have full activation of IFN-stimulated genes (ISGs). Preactivation of this endogenous IFN system is associated with nonresponse to pegylated IFN-α (pegIFN-α) and ribavirin. Genome-wide association studies have associated allelic variants near the IL28B ( IFNλ 3) gene with treatment response. We investigated whether IL28B genotype determines the constitutive expression of ISGs in the liver and compared the abilities of ISG levels and IL28B genotype to predict treatment outcome.

Journal

GastroenterologyElsevier

Published: Mar 1, 2011

References

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