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Interactions between viruses, cells and the host immune response that underlie the pathogenesis of viral diseases

<h5>Nomenclature</h5> ASFV – African swine fever virus HS – heparan sulfate SA – sialic acid VZV – varicella-zoster virus Viruses were the first pathogens to have complete sequence information available. At least one representative and, often, many representatives of each virus family have been sequenced. The genomes have revealed and continue to reveal much about the predicted types of viral proteins encoded, about virus evolution, conservation of genetic information, efficient use of small coding capacities, and about the significant consequences of apparently minor coding and noncoding changes for virulence. However, as more and more viruses have been sequenced, it has quickly become apparent that, even for those with the smallest genomes, obtaining the sequence is only a very first step toward understanding virus-induced disease. The ‘postgenomic era’ of virology has provided fascinating glimpses into the complexities of virus–host cell and virus–host interactions. One important lesson that is illustrated by studies of a number of viruses, including rotaviruses, varicella-zoster virus (VZV) and African swine fever virus (ASFV), is that investigation of the functions of many viral proteins cannot rely solely on studies of virus infection of tissue culture cells. Receptors that are used in vitro are often not the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Microbiology Elsevier
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