Integrating Networks and Proteomics: Moving Forward

Integrating Networks and Proteomics: Moving Forward Networks can resolve many analytical problems in proteomics, including incomplete coverage and inconsistency. Despite high expectations, network-related research in proteomics has experienced only modest growth. In practice, most current research examines non-quantitative usages, for example determining physical interactions among proteins or contextualizing a differential protein list, rather than addressing practical quantitative usages, for example predicting missing proteins or making sample-class predictions. Moreover, many applications are irreproducible and are not widely adopted owing to a lack of common standards, particularly evaluation criteria and gold-standard datasets. A concerted drive towards quantitative applications and convergence towards common standards is essential for ‘network-based proteomics’ to realize its development potential and make meaningful contributions to clinical applications. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Trends in Biotechnology Elsevier

Integrating Networks and Proteomics: Moving Forward

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Publisher
Elsevier Current Trends
Copyright
Copyright © 2016 Elsevier Ltd
ISSN
0167-7799
D.O.I.
10.1016/j.tibtech.2016.05.015
Publisher site
See Article on Publisher Site

Abstract

Networks can resolve many analytical problems in proteomics, including incomplete coverage and inconsistency. Despite high expectations, network-related research in proteomics has experienced only modest growth. In practice, most current research examines non-quantitative usages, for example determining physical interactions among proteins or contextualizing a differential protein list, rather than addressing practical quantitative usages, for example predicting missing proteins or making sample-class predictions. Moreover, many applications are irreproducible and are not widely adopted owing to a lack of common standards, particularly evaluation criteria and gold-standard datasets. A concerted drive towards quantitative applications and convergence towards common standards is essential for ‘network-based proteomics’ to realize its development potential and make meaningful contributions to clinical applications.

Journal

Trends in BiotechnologyElsevier

Published: Dec 1, 2016

References

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