In 1985, Jeffcott and Field 1 proposed a clinical condition in which hyperlipemia and laminitis were associated with stress and insulin insensitivity. Diminished oral glucose tolerance and intravenous insulin tolerance was demonstrated in obese and laminitic ponies compared with normal Standardbred horses. 2 Glucose and insulin tolerance are not, however, specific and unambiguous criteria of insulin sensitivity. 3 Nearly 20 years have transpired before the current specific and quantitative characterization of uncompensated insulin resistance in a hyperlipemic, laminitic pony. A 6-year-old small gelding was 153 kg with a body condition score of 5.5 (out of 9) when referred to the Marion duPont Equine Medical Center. It had a history of chronic respiratory disease, fever, a high Lyme titer, and laminitis. He had been treated with doxycycline and phenylbutazone but failed to respond. His diet had consisted of free choice orchard grass hay and approximately 220 g textured concentrate once a day. Clinical examination of the front feet with hoof testers was strongly positive for pain. Also, a bounding digital pulse was palpated in both front fetlocks. Radiographs showed a bilateral 8° rotation and excessive length of toe. Rectal temperature and heart rate were normal, but the respiratory rate
Journal of Equine Veterinary Science – Elsevier
Published: Jun 1, 2006
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