Insulin resistance and vascular function

Insulin resistance and vascular function It has become clear that amongst its many actions insulin is also a vasoactive hormone. Its effect to cause endothelial-nitric oxide-dependent vasodilation is physiologic and dose-dependent. Recent data suggest that insulin's metabolic and vascular actions are closely linked. Indeed, insulin resistant states , which by definition, exhibit diminished insulin-mediated glucose uptake into peripheral tissues also display impaired insulin mediated vasodilation as well as impaired endothelium dependent vasolidation to the muscarinic receptor agonist acetylcholine. Free fatty acids are elevated in states of insulin resistance and also cause endothelial dysfunction along with impaired insulin-mediated vasodilation. Thus, a picture is emerging linking insulin action in peripheral tissues to its action in endothelium. More recent data suggest that insulin signaling mechanisms in peripheral tissues and endothelium may be shared. Thus mechanisms causing insulin resistance via defects in insulin signaling might be expected to be manifest in both tissues. The protective action of nitric oxide and healthy endothelial function are critical to prevent atherosclerotic vascular disease. If follows that endothelial dysfunction associated insulin resistance through common defects in insulin signaling presents a parsimonious mechanism to account for the increased risk of cardiovascular disease associated with insulin resistance. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Diabetes and its Complications Elsevier

Insulin resistance and vascular function

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Publisher
Elsevier
Copyright
Copyright © 2002 Elsevier Science Inc.
ISSN
1056-8727
D.O.I.
10.1016/S1056-8727(01)00209-4
Publisher site
See Article on Publisher Site

Abstract

It has become clear that amongst its many actions insulin is also a vasoactive hormone. Its effect to cause endothelial-nitric oxide-dependent vasodilation is physiologic and dose-dependent. Recent data suggest that insulin's metabolic and vascular actions are closely linked. Indeed, insulin resistant states , which by definition, exhibit diminished insulin-mediated glucose uptake into peripheral tissues also display impaired insulin mediated vasodilation as well as impaired endothelium dependent vasolidation to the muscarinic receptor agonist acetylcholine. Free fatty acids are elevated in states of insulin resistance and also cause endothelial dysfunction along with impaired insulin-mediated vasodilation. Thus, a picture is emerging linking insulin action in peripheral tissues to its action in endothelium. More recent data suggest that insulin signaling mechanisms in peripheral tissues and endothelium may be shared. Thus mechanisms causing insulin resistance via defects in insulin signaling might be expected to be manifest in both tissues. The protective action of nitric oxide and healthy endothelial function are critical to prevent atherosclerotic vascular disease. If follows that endothelial dysfunction associated insulin resistance through common defects in insulin signaling presents a parsimonious mechanism to account for the increased risk of cardiovascular disease associated with insulin resistance.

Journal

Journal of Diabetes and its ComplicationsElsevier

Published: Jan 1, 2002

References

  • Insulin differentially regulates systemic and skeletal muscle vascular resistance
    Baron, A.D.; Brechtel, G.
  • Effect of perfusion rate on the time course of insulin mediated skeletal muscle glucose uptake
    Baron, A.D.; Brechtel-Hook, G.; Johnson, A.; Cronin, J.; Leaming, R.; Ho, S.
  • Hyperinsulinaemia as a predictor of coronary heart disease mortality in a healthy population: the Paris Prospective Study, 15-year follow-up
    Fontbonne, A.; Charles, M.A.; Thibult, N.; Richard, J.L.; Claude, J.R.; Warnet, J.M.; Rosselin, G.E.; Eschwege, E.
  • Differential effects of acute hypertriglyceridemia on insulin action and insulin receptor autophosphorylation
    Gumbiner, B.; Mucha, J.F.; Lindstrom, J.E.; Rekhi, I.; Livingston, J.N.
  • Pharmacological modulation of endothelial function by insulin in the rat aorta
    Laight, D.W.; Kaw, A.V.; Carrier, M.J.; Anggard, E.E.
  • Evidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow
    Mather, K.; Laakso, M.; Edelman, S.; Hook, G.; Baron, A.
  • Cell dysfunction in atherosclerosis and the ischemic manifestations of coronary artery disease
    Selwyn, A.P.; Kinlay, S.; Creager, M.; Libby, P.; Ganz, P.

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