Article history: Instrumented roll technology on Alexanderwerk WP120 roller compactor was developed and utilized Received 14 July 2011 successfully for the measurement of normal stress on ribbon during the process. The effects of process Received in revised form 10 January 2012 parameters such as roll speed (4–12 rpm), feed screw speed (19–53 rpm), and hydraulic roll pressure Accepted 15 January 2012 (40–70 bar) on normal stress and ribbon density were studied using placebo and active pre–blends. The Available online 25 January 2012 placebo blend consisted of 1:1 ratio of microcrystalline cellulose PH102 and anhydrous lactose with sodium croscarmellose, colloidal silicon dioxide, and magnesium stearate. The active pre-blends were Keywords: prepared using various combinations of one active ingredient (3–17%, w/w) and lubricant (0.1–0.9%, w/w) Roller compaction levels with remaining excipients same as placebo. Instrumented roll Three force transducers (load cells) were installed linearly along the width of the roll, equidistant from Process design space each other with one transducer located in the center. Normal stress values recorded by side sensors and Ribbon normal stress Ribbon density were lower than normal stress values recorded by middle sensor and showed greater variability than Vacuum de-aeration middle sensor. Normal stress was found to
International Journal of Pharmaceutics – Elsevier
Published: Apr 15, 2012
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