Instrumented roll technology for the design space development of roller compaction process

Instrumented roll technology for the design space development of roller compaction process Article history: Instrumented roll technology on Alexanderwerk WP120 roller compactor was developed and utilized Received 14 July 2011 successfully for the measurement of normal stress on ribbon during the process. The effects of process Received in revised form 10 January 2012 parameters such as roll speed (4–12 rpm), feed screw speed (19–53 rpm), and hydraulic roll pressure Accepted 15 January 2012 (40–70 bar) on normal stress and ribbon density were studied using placebo and active pre–blends. The Available online 25 January 2012 placebo blend consisted of 1:1 ratio of microcrystalline cellulose PH102 and anhydrous lactose with sodium croscarmellose, colloidal silicon dioxide, and magnesium stearate. The active pre-blends were Keywords: prepared using various combinations of one active ingredient (3–17%, w/w) and lubricant (0.1–0.9%, w/w) Roller compaction levels with remaining excipients same as placebo. Instrumented roll Three force transducers (load cells) were installed linearly along the width of the roll, equidistant from Process design space each other with one transducer located in the center. Normal stress values recorded by side sensors and Ribbon normal stress Ribbon density were lower than normal stress values recorded by middle sensor and showed greater variability than Vacuum de-aeration middle sensor. Normal stress was found to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Pharmaceutics Elsevier

Loading next page...
 
/lp/elsevier/instrumented-roll-technology-for-the-design-space-development-of-aUi00jZblZ
Publisher
Elsevier
Copyright
Copyright © 2012 Elsevier B.V.
ISSN
0378-5173
D.O.I.
10.1016/j.ijpharm.2012.01.032
Publisher site
See Article on Publisher Site

Abstract

Article history: Instrumented roll technology on Alexanderwerk WP120 roller compactor was developed and utilized Received 14 July 2011 successfully for the measurement of normal stress on ribbon during the process. The effects of process Received in revised form 10 January 2012 parameters such as roll speed (4–12 rpm), feed screw speed (19–53 rpm), and hydraulic roll pressure Accepted 15 January 2012 (40–70 bar) on normal stress and ribbon density were studied using placebo and active pre–blends. The Available online 25 January 2012 placebo blend consisted of 1:1 ratio of microcrystalline cellulose PH102 and anhydrous lactose with sodium croscarmellose, colloidal silicon dioxide, and magnesium stearate. The active pre-blends were Keywords: prepared using various combinations of one active ingredient (3–17%, w/w) and lubricant (0.1–0.9%, w/w) Roller compaction levels with remaining excipients same as placebo. Instrumented roll Three force transducers (load cells) were installed linearly along the width of the roll, equidistant from Process design space each other with one transducer located in the center. Normal stress values recorded by side sensors and Ribbon normal stress Ribbon density were lower than normal stress values recorded by middle sensor and showed greater variability than Vacuum de-aeration middle sensor. Normal stress was found to

Journal

International Journal of PharmaceuticsElsevier

Published: Apr 15, 2012

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial