Insights to the minimal model of insulin secretion through a mean-field beta cell model

Insights to the minimal model of insulin secretion through a mean-field beta cell model The present work introduces an extension of the original minimal model of second phase insulin secretion during the intravenous glucose tolerance test (IVGTT), which can provide both physiological and mathematical insights to the minimal model. The extension is named the mean-field beta cell model since it returns the average response of a large number of nonlinear secretory entities. Several secretion models have been proposed for the IVGTT, and we shall identify two fundamentally different theoretical features of these models. Both features can play a central role during the IVGTT, including the one presented in the mean-field beta cell model. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Theoretical Biology Elsevier

Insights to the minimal model of insulin secretion through a mean-field beta cell model

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Publisher
Elsevier
Copyright
Copyright © 2005 Elsevier Ltd
ISSN
0022-5193
eISSN
1095-8541
D.O.I.
10.1016/j.jtbi.2005.04.023
Publisher site
See Article on Publisher Site

Abstract

The present work introduces an extension of the original minimal model of second phase insulin secretion during the intravenous glucose tolerance test (IVGTT), which can provide both physiological and mathematical insights to the minimal model. The extension is named the mean-field beta cell model since it returns the average response of a large number of nonlinear secretory entities. Several secretion models have been proposed for the IVGTT, and we shall identify two fundamentally different theoretical features of these models. Both features can play a central role during the IVGTT, including the one presented in the mean-field beta cell model.

Journal

Journal of Theoretical BiologyElsevier

Published: Dec 21, 2005

References

  • Comparison of storage- and signal-limited models of pancreatic insulin secretion
    O’Connor, M.D.; Landahl, H.; Grodsky, G.M.
  • Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells
    Olofsson, C.S.; Gopel, S.O.; Barg, S.; Galvanovskis, J.; Ma, X.; Salehi, A.; Rorsman, P.; Eliasson, L.
  • Insulin granule dynamics in pancreatic beta cells
    Rorsman, P.; Renstrom, E.

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