Pediatric Neurology 80 (2018) 88–89 Contents lists available at ScienceDirect Pediatric Neurology journal homepage: www.elsevier.com/locate/pnu Research Letter Initial Observations of Salivary Brain-Derived Neurotrophic Factor Levels in Rett Syndrome a, b c Breanne Byiers PhD *, Chantel Barney PhD , Michael Ehrhardt PhD , c d e Angela Panoskaltsis-Mortari PhD , Timothy Feyma MD , Arthur Beisang MD , Frank J. Symons PhD Department of Educational Psychology, University of Minnesota, Minneapolis, Minnesota Research Administration, Gillette Children’s Specialty Healthcare, Saint Paul, Minnesota Department of Pediatrics, Division of Blood and Marrow Transplantation, Cytokine Reference Laboratory, University of Minnesota, Minneapolis, Minnesota Neurology, Gillette Children’s Specialty Healthcare, Saint Paul, Minnesota Pediatrics, Gillette Children’s Specialty Healthcare, Saint Paul, Minnesota of participation. Three participants (19%) could walk without support, Rett syndrome (RTT) is a neurodevelopmental disorder, and six participants (38%) had nutritional needs met via gastrostomy affecting primarily females, caused by mutations in the tubes. methyl-CpG-binding protein (MECP2) 2 gene. Altered ex- pression of brain-derived neurotrophic factor (BDNF) has Specimen collection and processing been implicated in the pathogenesis of RTT. Clinical evi- dence of altered BDNF concentrations in central and Saliva was collected during a routine clinic visit. Approximately 3 mL peripheral samples in humans has
Pediatric Neurology – Elsevier
Published: Mar 1, 2018
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