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We performed a structure -activity relationship (SAR) study of a novel aspirin (ASA) derivative, which shows strong anticancer activity in vitro and in vivo. A series of ASA-based benzyl esters (ABEs ...
Using molecular hybridization and bioisosteric replacement approaches, novel agents with potential use for the treatment of Alzheimer’s disease (AD) were developed based on the structure of donepezil ...
A series of novel 1,4‐dihydrothieno[3′,2′:5,6]thiopyrano[4,3‐c]‐pyrazole‐3‐carboxamide derivatives were synthesized and evaluated for their inhibitory activity to human 5‐lipo‐oxygenase (5‐LOX ...
. MEDICINAL Med Chem Res (2015) 24:1038–1059 CHEMISTRY DOI 10.1007/s00044-014-1163-1 RESEARCH OR IGINAL RESEARCH Structural insights into mode of actions of novel substituted 4- and 6-azaindole-3-carboxamides ...
Two novel series of human immunodeficiency virus‐1 (HIV‐1) non‐nucleoside reverse transcriptase inhibitors (NNRTIs) bearing a thiophene[3,2‐d]pyrimidine scaffold and sulfonamide linker in the right ...
, structural modifications were performed on paeoniflorin through a series of responses, including acetylation, deacetylation, and debenzoylation, ultimately yielding 46 monoterpene glycoside derivatives ...
In the quest to treat diabetes, nowadays, the enthusiasm for the development of novel drugs with strong α-glucosidase inhibitory action and negligible or no adverse effects has received great ...
Two series of novel 2-thiazolylhydrazone derivatives were designed and synthesized via one-pot reaction of benzaldehyde derivatives, $$\alpha $$ α -haloketones and thiosemicarbazide ...
The inhibitory properties of a series of both N‐linked and C‐linked C1‐substituted glucose derivatives towards glycogen phosphorylase (GP) activity from crude extracts of rat liver and muscle have ...
multiple linear regression (MLR) based on quantitative structure –activity relationships (QSAR). The models were shown to have highly predictive ability and stability, and provided insight into the inhibitory ...
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