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protein expression in both drug- sensitive OS cells and drug-resistant OS cells, while inhibiting STAT3 with siRNA sensitized OS cells to doxorubicin treatment. In addition, RA synergistically increased ...
expression, increased nuclear translocation of phospho- Stat3 , and binding to DNA occurred only in resistant SKN-SH/Dox6 cells. The expression of Bcl-xL was inhibited by AG490, an inhibitor of the JAK/ Stat3 ...
) when compared with human renal proximal tubule epithelial cell line HK-2. The inhibition of IL-6 by siRNA can suppress the proliferation, migration and invasion of RCC cells and increase the doxorubicin ...
sleep‐wake cycles, is associated with a significantly increased risk of breast cancer and resistance to tamoxifen and doxorubicin . Melatonin inhibition of human breast cancer chemoresistance involves ...
, and increased doxorubicin sensitivity . Conversely, PIM1 overexpression in TCL cells induced c-myc expression, suppressed TCL cell death, and promoted doxorubicin resistance. Collectively, our results demonstrate ...
Search ADS PubMed WorldCat Gariboldi MB et al. Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line . Cancer Lett 2007 ; 258 : 181 – 188 . Google Scholar ...
and negatively correlated with the expression level of MRP1. The miR-145 directly targets MRP1 mRNA at 3′-UTR and increases sensitivity to doxorubicin by inducing intracellular drug accumulation.[23] With the same ...
of cyclophosphamide, doxorubicin , vincristine, and prednisone (CHOP). The involvement of ALDH1A1 in DLBCL was elucidated by knockdown and pharmacologic inhibition ; Cell Counting Kit-8 (CCK-8) and clone formation assays ...
sensitizer cooperating with anticancer drugs to combat chemoresistant carcinoma through the inhibition of the Nrf2 pathway. IntroductionLung carcinoma is a main cause disturbing public health in the world [1 ...
(Student’s t-test). (B) Inhibition of the activation of the MAPK and JAK2/ STAT3 signaling pathways in cancer cells by tamoxifen. The expression of pERK and pJAK2/pSTAT3 signaling in human breast cancer cells ...
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