Inhibition of NMDA receptors and nitric oxide synthase reduces ischemic injury of the retina

Inhibition of NMDA receptors and nitric oxide synthase reduces ischemic injury of the retina This study was performed to examine the roles of body temperature, NMDA receptors and nitric oxide (NO) synthase in post-ischemic retinal injury in rats. Cell loss in the ganglion cell layer and thinning of the inner plexiform layer were observed 7 days after ischemia. Cell loss in the ganglion cell layer but not thinning of the inner plexiform layer was reduced by hypothermia during ischemia. Intravenous injection of dizocilpine (MK-801) or N ω -nitro- l -arginine methyl ester ( l -NAME) prior to ischemia ameliorated retinal injury. These results suggest that activation of NO synthase following NMDA receptor stimulation is involved in ischemia-induced retinal injury. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Pharmacology Elsevier

Inhibition of NMDA receptors and nitric oxide synthase reduces ischemic injury of the retina

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Publisher
Elsevier
Copyright
Copyright © 1998 Elsevier Science B.V.
ISSN
0014-2999
D.O.I.
10.1016/S0014-2999(98)00317-3
Publisher site
See Article on Publisher Site

Abstract

This study was performed to examine the roles of body temperature, NMDA receptors and nitric oxide (NO) synthase in post-ischemic retinal injury in rats. Cell loss in the ganglion cell layer and thinning of the inner plexiform layer were observed 7 days after ischemia. Cell loss in the ganglion cell layer but not thinning of the inner plexiform layer was reduced by hypothermia during ischemia. Intravenous injection of dizocilpine (MK-801) or N ω -nitro- l -arginine methyl ester ( l -NAME) prior to ischemia ameliorated retinal injury. These results suggest that activation of NO synthase following NMDA receptor stimulation is involved in ischemia-induced retinal injury.

Journal

European Journal of PharmacologyElsevier

Published: May 29, 1998

References

  • The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia
    Dalkara, T.; Moskowitz, M.A.
  • A novel neuronal messenger molecule in brain: the free radical, nitric oxide
    Dawson, T.M.; Dawson, V.L.; Snyder, S.H.
  • Dual actions of nitric oxide in N -methyl- d -aspartate receptor-mediated neurotoxicity in cultured retinal neurons
    Kashii, S.; Mandai, M.; Kikuchi, M.; Honda, Y.; Tamura, Y.; Kaneda, K.; Akaike, A.

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