Inhibition of Japanese encephalitis virus infection in vitro and in vivo by pokeweed antiviral protein

Inhibition of Japanese encephalitis virus infection in vitro and in vivo by pokeweed antiviral... Highlights ► Pokeweed antiviral protein (PAP) was expressed and purified from E. coli system. ► PAP suppressed JEV infection in vitro . ► The 50% inhibitory concentration (IC 50 ) was 300 ng/ml (23.1 nM). ► PAP can decrease mortality in mice challenged with a lethal dose of JEV. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Virus Research Elsevier

Inhibition of Japanese encephalitis virus infection in vitro and in vivo by pokeweed antiviral protein

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Publisher
Elsevier
Copyright
Copyright © 2012 Elsevier B.V.
ISSN
0168-1702
D.O.I.
10.1016/j.virusres.2012.10.032
Publisher site
See Article on Publisher Site

Abstract

Highlights ► Pokeweed antiviral protein (PAP) was expressed and purified from E. coli system. ► PAP suppressed JEV infection in vitro . ► The 50% inhibitory concentration (IC 50 ) was 300 ng/ml (23.1 nM). ► PAP can decrease mortality in mice challenged with a lethal dose of JEV.

Journal

Virus ResearchElsevier

Published: Jan 1, 2013

References

  • High-level expression and purification of biologically active recombinant pokeweed antiviral protein
    Rajamohan, F.; Engstrom, C.R.; Denton, T.J.; Engen, L.A.; Kourinov, I.; Uckun, F.M.
  • Deguanylation of human immunodeficiency virus (HIV-1) RNA by recombinant pokeweed antiviral protein
    Rajamohan, F.; Kurinov, I.V.; Venkatachalam, T.K.; Uckun, F.M.
  • Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus (HIV)-1
    Rajamohan, F.; Venkatachalam, T.K.; Irvin, J.D.; Uckun, F.M.

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