Inhibition of JAK1 by microRNA-708 promotes SH-SY5Y neuronal cell survival after oxygen and glucose deprivation and reoxygenation

Inhibition of JAK1 by microRNA-708 promotes SH-SY5Y neuronal cell survival after oxygen and... •Human neuroblastoma cells (SH-SY5Y) downregulated miR-708 and upregulated JAK after OGD/R treatment.•Silence of miR-708 can promote OGD/R SH-SY5Y cell proliferation migration and invasion.•JAK1 as a direct target of miR-708.•A reversed correlation existed between miR-708 and JAK1 mRNA levels in OGD/R SH-SY5Y. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Inhibition of JAK1 by microRNA-708 promotes SH-SY5Y neuronal cell survival after oxygen and glucose deprivation and reoxygenation

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0304-3940
D.O.I.
10.1016/j.neulet.2017.11.017
Publisher site
See Article on Publisher Site

Abstract

•Human neuroblastoma cells (SH-SY5Y) downregulated miR-708 and upregulated JAK after OGD/R treatment.•Silence of miR-708 can promote OGD/R SH-SY5Y cell proliferation migration and invasion.•JAK1 as a direct target of miR-708.•A reversed correlation existed between miR-708 and JAK1 mRNA levels in OGD/R SH-SY5Y.

Journal

Neuroscience LettersElsevier

Published: Jan 18, 2018

References

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