Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome

Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome Bioorganic & Medicinal Chemistry Letters 30 (2020) 126997 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome a,b a,c, a,c d b Elyza Aiman Azizah Nur , Taichi Ohshiro , Keisuke Kobayashi , Jing Wu , Elly Wahyudin , e e d a,c, Huiping Zhang , Fumiaki Hayashi , Hirokazu Kawagishi , Hiroshi Tomoda Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan Faculty of Pharmacy, Hasanuddin University, Perintis Kemerdekaan Tamalanrea, Makassar 90245, South Sulawesi, Indonesia Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan NMR Science and Development Division, RIKEN Spring-8 Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan ARTICLE INFO ABSTRACT Keywords: Using activity guided purification, four known compounds, sesquiterpene atractylenolide III (1), and the poly- Sesquiterpene acetylenes 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol (2), 14-acetoxy-12-α-methyl- Polyacetylene butyl-2E,8E,10E-trien-4,6-diyn-1-ol (3), and 14-acetoxy-12-β -methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol (4), Cholesteryl ester synthesis were isolated from a traditional herbal medicine, Atractylodes rhizome. Structurally similar 3 and 4 (3/4 mix- Sterol O-acyltransferase ture) were obtained as a mixture. In intact Chinese hamster http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Bioorganic & Medicinal Chemistry Letters Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2020 Elsevier Ltd
ISSN
0960-894x
DOI
10.1016/j.bmcl.2020.126997
Publisher site
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Abstract

Bioorganic & Medicinal Chemistry Letters 30 (2020) 126997 Contents lists available at ScienceDirect Bioorganic & Medicinal Chemistry Letters journal homepage: www.elsevier.com/locate/bmcl Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome a,b a,c, a,c d b Elyza Aiman Azizah Nur , Taichi Ohshiro , Keisuke Kobayashi , Jing Wu , Elly Wahyudin , e e d a,c, Huiping Zhang , Fumiaki Hayashi , Hirokazu Kawagishi , Hiroshi Tomoda Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan Faculty of Pharmacy, Hasanuddin University, Perintis Kemerdekaan Tamalanrea, Makassar 90245, South Sulawesi, Indonesia Medicinal Research Laboratories, School of Pharmacy, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan Research Institute of Green Science and Technology, Shizuoka University, 836 Ohya, Suruga-ku, Shizuoka 422-8529, Japan NMR Science and Development Division, RIKEN Spring-8 Center, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan ARTICLE INFO ABSTRACT Keywords: Using activity guided purification, four known compounds, sesquiterpene atractylenolide III (1), and the poly- Sesquiterpene acetylenes 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol (2), 14-acetoxy-12-α-methyl- Polyacetylene butyl-2E,8E,10E-trien-4,6-diyn-1-ol (3), and 14-acetoxy-12-β -methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol (4), Cholesteryl ester synthesis were isolated from a traditional herbal medicine, Atractylodes rhizome. Structurally similar 3 and 4 (3/4 mix- Sterol O-acyltransferase ture) were obtained as a mixture. In intact Chinese hamster

Journal

Bioorganic & Medicinal Chemistry LettersElsevier

Published: Apr 1, 2020

References

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