Indicators of immune activation in major depression

Indicators of immune activation in major depression Immune-inflammatory markers and their correlations were examined in patients with major depression. Plasma concentrations of interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), soluble interleukin-2 receptor (sIL-2R), transferrin receptor (TfR), C-reactive protein (CRP), and α 1 -acid glycoprotein (AGP), as well as the microheterogeneity of AGP, were measured in 49 major depressed patients during an acute phase of the illness and compared with concentrations in 15 normal control subjects. Plasma concentrations of IL-6, sIL-6, sIL-2R, TfR, CRP, and AGP were significantly higher in major depressed patients than in healthy control subjects. Patients with higher values of AGP microheterogeneity coefficient (AGP-RC > 1.5) had significantly higher concentrations of AGP, IL-6, and TfR. The correlations between cytokines and acute phase proteins studied point to a significant role of elevated IL-6 secretion in the induction of Type I AGP microheterogeneity changes that are characteristic of some inflammatory conditions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychiatry Research Elsevier

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Publisher
Elsevier
Copyright
Copyright © 1996 Elsevier Ltd
ISSN
0165-1781
D.O.I.
10.1016/S0165-1781(96)02783-7
Publisher site
See Article on Publisher Site

Abstract

Immune-inflammatory markers and their correlations were examined in patients with major depression. Plasma concentrations of interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), soluble interleukin-2 receptor (sIL-2R), transferrin receptor (TfR), C-reactive protein (CRP), and α 1 -acid glycoprotein (AGP), as well as the microheterogeneity of AGP, were measured in 49 major depressed patients during an acute phase of the illness and compared with concentrations in 15 normal control subjects. Plasma concentrations of IL-6, sIL-6, sIL-2R, TfR, CRP, and AGP were significantly higher in major depressed patients than in healthy control subjects. Patients with higher values of AGP microheterogeneity coefficient (AGP-RC > 1.5) had significantly higher concentrations of AGP, IL-6, and TfR. The correlations between cytokines and acute phase proteins studied point to a significant role of elevated IL-6 secretion in the induction of Type I AGP microheterogeneity changes that are characteristic of some inflammatory conditions.

Journal

Psychiatry ResearchElsevier

Published: Oct 16, 1996

References

  • Monokines regulate glycosylation of acute phase proteins
    Mackiewicz, A.; Ganapathi, M.K.; Shultz, D.; Kushner, I.
  • A soluble form of the human transferrin receptor is released by activated lymphocytes in vitro
    Woith, W.; Nusslein, I.; Antoni, C.; Dejica, D.I.; Winkler, T.A.; Harrmann, M.; Pirner, K.; Kalden, J.R.; Manger, B.
  • Soluble interleukin 2 receptor in systemic lupus erythematosus
    Wolf, R.E.; Brelsford, W.G.
  • Accessory factors involved in murine T cell activation. Distinct roles of interleukin-6, interleukin-1 and tumor necrosis factor
    Vink, A.; Uyttenhove, C.; Wauters, P.; Van Snick, J.

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