Increased expression of Semaphorin 3A in the endothelin receptor-B null mouse model of Hirschsprung disease

Increased expression of Semaphorin 3A in the endothelin receptor-B null mouse model of... PurposeSemaphorins are guidance cues for developing neurons, implicated in the determination of the migratory pathway of neural crest-derived neural precursors during enteric nervous system development. Recently, it has been reported that Semaphorin 3A (SEMA3A) expression is up-regulated in the aganglionic colon in Hirschsprung disease (HD) patients, suggesting that increased SEMA3A expression may be a risk factor for HD. Thus, the aim of our study was to determine the expression of SEMA3A using Sox10-Venus mice gut. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Pediatric Surgery Elsevier

Increased expression of Semaphorin 3A in the endothelin receptor-B null mouse model of Hirschsprung disease

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Inc.
ISSN
0022-3468
D.O.I.
10.1016/j.jpedsurg.2017.11.034
Publisher site
See Article on Publisher Site

Abstract

PurposeSemaphorins are guidance cues for developing neurons, implicated in the determination of the migratory pathway of neural crest-derived neural precursors during enteric nervous system development. Recently, it has been reported that Semaphorin 3A (SEMA3A) expression is up-regulated in the aganglionic colon in Hirschsprung disease (HD) patients, suggesting that increased SEMA3A expression may be a risk factor for HD. Thus, the aim of our study was to determine the expression of SEMA3A using Sox10-Venus mice gut.

Journal

Journal of Pediatric SurgeryElsevier

Published: Feb 1, 2018

References

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