In vivo estrogenic activity of branched and linear alkylphenols in rainbow trout ( Oncorhynchus mykiss )

In vivo estrogenic activity of branched and linear alkylphenols in rainbow trout ( Oncorhynchus... The in vivo estrogenic activity of the two branched alkylphenols, tert -octylphenol and technical nonylphenol, and the two linear isoforms, n -octylphenol and n -nonylphenol, was compared. The compounds were administered to juvenile rainbow trout ( Oncorhynchus mykiss ) by either intraperitoneal injection or water exposure and their estrogenic potential was evaluated by ELISA measurements of induced plasma vitellogenin. Intraperitoneal injections (50 mg/kg) of the two branched alkylphenols resulted in a significant vitellogenic response after 12 days whereas no significant induction was seen with the two linear isomers. Water exposure for 9 days to a nominal concentration of 150 μg/l of the alkylphenols elicited the same response pattern as seen for the injection experiment. Furthermore, in the present vitellogenin assay tert -octylphenol was giving a higher estrogenic response compared to technical nonylphenol using either of the two exposure routes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Science of the Total Environment Elsevier

In vivo estrogenic activity of branched and linear alkylphenols in rainbow trout ( Oncorhynchus mykiss )

Loading next page...
 
/lp/elsevier/in-vivo-estrogenic-activity-of-branched-and-linear-alkylphenols-in-75C3oXbuT0
Publisher
Elsevier
Copyright
Copyright © 1999 Elsevier Science B.V.
ISSN
0048-9697
eISSN
1879-1026
DOI
10.1016/S0048-9697(99)00182-5
Publisher site
See Article on Publisher Site

Abstract

The in vivo estrogenic activity of the two branched alkylphenols, tert -octylphenol and technical nonylphenol, and the two linear isoforms, n -octylphenol and n -nonylphenol, was compared. The compounds were administered to juvenile rainbow trout ( Oncorhynchus mykiss ) by either intraperitoneal injection or water exposure and their estrogenic potential was evaluated by ELISA measurements of induced plasma vitellogenin. Intraperitoneal injections (50 mg/kg) of the two branched alkylphenols resulted in a significant vitellogenic response after 12 days whereas no significant induction was seen with the two linear isomers. Water exposure for 9 days to a nominal concentration of 150 μg/l of the alkylphenols elicited the same response pattern as seen for the injection experiment. Furthermore, in the present vitellogenin assay tert -octylphenol was giving a higher estrogenic response compared to technical nonylphenol using either of the two exposure routes.

Journal

Science of the Total EnvironmentElsevier

Published: Aug 15, 1999

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off