The in vivo estrogenic activity of the two branched alkylphenols, tert -octylphenol and technical nonylphenol, and the two linear isoforms, n -octylphenol and n -nonylphenol, was compared. The compounds were administered to juvenile rainbow trout ( Oncorhynchus mykiss ) by either intraperitoneal injection or water exposure and their estrogenic potential was evaluated by ELISA measurements of induced plasma vitellogenin. Intraperitoneal injections (50 mg/kg) of the two branched alkylphenols resulted in a significant vitellogenic response after 12 days whereas no significant induction was seen with the two linear isomers. Water exposure for 9 days to a nominal concentration of 150 μg/l of the alkylphenols elicited the same response pattern as seen for the injection experiment. Furthermore, in the present vitellogenin assay tert -octylphenol was giving a higher estrogenic response compared to technical nonylphenol using either of the two exposure routes.
Science of the Total Environment – Elsevier
Published: Aug 15, 1999
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