Article history: Silica xerogel as a potential drug carrier system for the in vivo as well as in vitro delivery of andro- Received 7 July 2015 grapholide was tested. The present study aims to optimize the effective experimental parameters; volume Received in revised form 7 November 2015 of ethanol, volume of water and drying temperature by applying response surface methodology coupled Accepted 9 November 2015 with Box–Behnken experimental design. The in vitro drug release in simulated body ﬂuid at 37 C from Available online 14 November 2015 the selected formulation was signiﬁcantly highest (44.83 ± 0.9%) among rest of the formulations. Results indicate that sol–gel method is useful for entrapping andrographolide in the silica gel and for releasing Keywords: the same via diffusion through the porous matrix under the in vitro/in vivo conditions. Silica gel exhibited Box–Behnken design slow matrix degradation as well as sustained release of andrographolide within the experimental time Response surface methodology frame of 168 h. In vivo study was performed with three increasing doses [2 mg (S1), 8 mg (S2), and 16 mg Drug release (S3)] of silica. Histological fates of different organs were executed with those doses. Optimization Matrix degradation © 2015 Elsevier B.V.
Applied Surface Science – Elsevier
Published: Jan 1, 2016
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