In vitro evaluation and physicochemical characteristics of casein phosphopeptides-soluble dietary fibers copolymers as a novel calcium delivery system

In vitro evaluation and physicochemical characteristics of casein phosphopeptides-soluble... The absorption of calcium by the human body is limited due to the formation of calcium phosphate deposits during gastrointestinal digestion. A new type of calcium delivery system was established using casein phosphopeptides (CPP) and soluble dietary fibers (SDF) through covalent binding. The physicochemical properties, morphology, calcium binding mechanisms, and in vitro calcium release behavior of the prepared CPP-SDF copolymers in a simulated gastrointestinal tract were investigated. The results showed that the maximum calcium binding level of the copolymers reached 46.8%, 35.17% (p < 0.05) greater than that of the original CPP. The calcium binding mechanism of the copolymers was the chemical grafting of active groups; exposed -CO-NH, -COOH and -OH groups and the imidazole group of His served as the major binding sites. In addition, the grafted SDF formed a shell to diminish the digestion of peptides and prolong the release of calcium in the gastrointestinal tract. Therefore, the prepared CPP-SDF copolymers are a promising calcium delivery vehicle for improving calcium bioavailability. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Food Hydrocolloids Elsevier

In vitro evaluation and physicochemical characteristics of casein phosphopeptides-soluble dietary fibers copolymers as a novel calcium delivery system

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0268-005X
eISSN
1873-7137
D.O.I.
10.1016/j.foodhyd.2018.01.024
Publisher site
See Article on Publisher Site

Abstract

The absorption of calcium by the human body is limited due to the formation of calcium phosphate deposits during gastrointestinal digestion. A new type of calcium delivery system was established using casein phosphopeptides (CPP) and soluble dietary fibers (SDF) through covalent binding. The physicochemical properties, morphology, calcium binding mechanisms, and in vitro calcium release behavior of the prepared CPP-SDF copolymers in a simulated gastrointestinal tract were investigated. The results showed that the maximum calcium binding level of the copolymers reached 46.8%, 35.17% (p < 0.05) greater than that of the original CPP. The calcium binding mechanism of the copolymers was the chemical grafting of active groups; exposed -CO-NH, -COOH and -OH groups and the imidazole group of His served as the major binding sites. In addition, the grafted SDF formed a shell to diminish the digestion of peptides and prolong the release of calcium in the gastrointestinal tract. Therefore, the prepared CPP-SDF copolymers are a promising calcium delivery vehicle for improving calcium bioavailability.

Journal

Food HydrocolloidsElsevier

Published: Jun 1, 2018

References

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