Available online at www.sciencedirect.com ScienceDirect Improving the discovery of secondary metabolite natural products using ion mobility–mass spectrometry 1 1,2 Alexandra C Schrimpe-Rutledge , Stacy D Sherrod and 1,2 John A McLean Secondary metabolite discovery requires an unbiased, metabolomics, which aims to comprehensively measure comprehensive workﬂow to detect unknown unknowns for all analytes within a biological sample, has the potential to which little to no molecular knowledge exists. Untargeted mass address this chemical diversity. A mass spectrometry spectrometry-based metabolomics is a powerful platform, (MS)-based metabolomic platform is a powerful approach particularly when coupled with ion mobility for high-throughput with high sensitivity and speciﬁcity . In a typical gas-phase separations to increase peak capacity and obtain experiment, the MS scans over a deﬁned mass range to gas-phase structural information. Ion mobility data are detect ions related to metabolites of interest. The number described by the amount of time an ion spends in the drift cell, of compounds detected depends on the resolving power which is directly related to an ion’s collision cross section of the separation platform(s). Pre-ionization separations (CCS). The CCS parameter describes the size, shape, and are routinely interfaced with MS; liquid chromatography charge of a molecule and can
Current Opinion in Chemical Biology – Elsevier
Published: Feb 1, 2018
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