Improving the discovery of secondary metabolite natural products using ion mobility–mass spectrometry

Improving the discovery of secondary metabolite natural products using ion mobility–mass... Available online at www.sciencedirect.com ScienceDirect Improving the discovery of secondary metabolite natural products using ion mobility–mass spectrometry 1 1,2 Alexandra C Schrimpe-Rutledge , Stacy D Sherrod and 1,2 John A McLean Secondary metabolite discovery requires an unbiased, metabolomics, which aims to comprehensively measure comprehensive workflow to detect unknown unknowns for all analytes within a biological sample, has the potential to which little to no molecular knowledge exists. Untargeted mass address this chemical diversity. A mass spectrometry spectrometry-based metabolomics is a powerful platform, (MS)-based metabolomic platform is a powerful approach particularly when coupled with ion mobility for high-throughput with high sensitivity and specificity [4]. In a typical gas-phase separations to increase peak capacity and obtain experiment, the MS scans over a defined mass range to gas-phase structural information. Ion mobility data are detect ions related to metabolites of interest. The number described by the amount of time an ion spends in the drift cell, of compounds detected depends on the resolving power which is directly related to an ion’s collision cross section of the separation platform(s). Pre-ionization separations (CCS). The CCS parameter describes the size, shape, and are routinely interfaced with MS; liquid chromatography charge of a molecule and can http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Chemical Biology Elsevier

Improving the discovery of secondary metabolite natural products using ion mobility–mass spectrometry

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier Ltd
ISSN
1367-5931
D.O.I.
10.1016/j.cbpa.2017.12.004
Publisher site
See Article on Publisher Site

Abstract

Available online at www.sciencedirect.com ScienceDirect Improving the discovery of secondary metabolite natural products using ion mobility–mass spectrometry 1 1,2 Alexandra C Schrimpe-Rutledge , Stacy D Sherrod and 1,2 John A McLean Secondary metabolite discovery requires an unbiased, metabolomics, which aims to comprehensively measure comprehensive workflow to detect unknown unknowns for all analytes within a biological sample, has the potential to which little to no molecular knowledge exists. Untargeted mass address this chemical diversity. A mass spectrometry spectrometry-based metabolomics is a powerful platform, (MS)-based metabolomic platform is a powerful approach particularly when coupled with ion mobility for high-throughput with high sensitivity and specificity [4]. In a typical gas-phase separations to increase peak capacity and obtain experiment, the MS scans over a defined mass range to gas-phase structural information. Ion mobility data are detect ions related to metabolites of interest. The number described by the amount of time an ion spends in the drift cell, of compounds detected depends on the resolving power which is directly related to an ion’s collision cross section of the separation platform(s). Pre-ionization separations (CCS). The CCS parameter describes the size, shape, and are routinely interfaced with MS; liquid chromatography charge of a molecule and can

Journal

Current Opinion in Chemical BiologyElsevier

Published: Feb 1, 2018

References

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