Implication of endogenous opioid system in the learned helplessness model of depression

Implication of endogenous opioid system in the learned helplessness model of depression The involvement of opioid system on the learned helplessness model of depression was investigated. Animals preexposed to inescapable shocks were treated with either Met-enkephalin, Leu-enkephalin, morphine, imipramine, naloxone, RB 38A (a mixed inhibitor of enkephalin degrading enzymes), or RB 38B (a selective inhibitor of neutral endopeptidase EC 3.4.24.11). Stimulation of opioid system by either opioid agonists or enkephalin catabolism inhibitors reversed the escape deficit induced by shock pretreatment. In contrast, administration of naloxone potentiated the effect of inescapable shocks. Imipramine reduced the number of escape failures in this test, and this effect was antagonized by naloxone. These results point to the involvement of the endogenous opioid system in this model of depression. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacology Biochemistry and Behavior Elsevier

Implication of endogenous opioid system in the learned helplessness model of depression

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Ltd
ISSN
0091-3057
eISSN
1873-5177
DOI
10.1016/0091-3057(95)00067-7
Publisher site
See Article on Publisher Site

Abstract

The involvement of opioid system on the learned helplessness model of depression was investigated. Animals preexposed to inescapable shocks were treated with either Met-enkephalin, Leu-enkephalin, morphine, imipramine, naloxone, RB 38A (a mixed inhibitor of enkephalin degrading enzymes), or RB 38B (a selective inhibitor of neutral endopeptidase EC 3.4.24.11). Stimulation of opioid system by either opioid agonists or enkephalin catabolism inhibitors reversed the escape deficit induced by shock pretreatment. In contrast, administration of naloxone potentiated the effect of inescapable shocks. Imipramine reduced the number of escape failures in this test, and this effect was antagonized by naloxone. These results point to the involvement of the endogenous opioid system in this model of depression.

Journal

Pharmacology Biochemistry and BehaviorElsevier

Published: Sep 1, 1995

References

  • Influence of naloxone on antidepressant drug effects in the forced-swimming test in mice
    Devoize, J.L.; Rigal, F.; Eschalier, A.; Trolèse, J.F.; Renoux, M.
  • The involvement of endogenous opiate system in learned helplessness and stress-induced analgesia
    Hemingway, R.B.; Reigle, T.G.
  • Noradrenergic and opioid mediation of tricyclic-induced reversal of escape deficits caused by inescapable shock pretreatment in rats
    Martin, P.; Soubrié, P.; Simon, P.
  • Guest editorial
    Zimmermann, M.

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