Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine depletion in rats

Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine... Rats with unilateral domapine (DA) depletions (hemi-Parkinson rats) display directional biases in their locomotion in spontaneous and drug induced tests. These biases have been explained as being due either to changed responsiveness to sensory stimulation, changes in motor ability, or to central changes, but as yet their basis is not fully understood. The purpose of the present experiment is to examine the posture of immobility and the posture and strategies of locomotion in rats with unilateral DA depletions. The rats are found to display impairments in their bad limbs (contralateral-to-lesion limbs) in adjusting posture and moving. They compensate by supporting themselves mainly on their good hindlimb, using the bad hindlimb and tail for balance and by disproportionately relying upon their good limbs to turn and to walk. Thus, their center of gravity is shifted to the good side and movement is preferentially directed toward the good side, in part to maintain equilibrium and in part to remove weight from the bad limbs so that they can enter the swing phase of the stepping cycle. It is proposed that the bad limbs may be unable to apply force to adjust posture and produce movement. These results provide a basis for predicting the movements that the animals will use in various situations and they expand the test repertoire this hemi-Parkinson model provides for studying recovery processes after loss of dopamine. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Brain Research Elsevier

Impairments and compensatory adjustments in spontaneous movement after unilateral dopamine depletion in rats

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Publisher
Elsevier
Copyright
Copyright © 1995 Elsevier Science B.V. All rights reserved
ISSN
0006-8993
D.O.I.
10.1016/0006-8993(95)00277-W
Publisher site
See Article on Publisher Site

Abstract

Rats with unilateral domapine (DA) depletions (hemi-Parkinson rats) display directional biases in their locomotion in spontaneous and drug induced tests. These biases have been explained as being due either to changed responsiveness to sensory stimulation, changes in motor ability, or to central changes, but as yet their basis is not fully understood. The purpose of the present experiment is to examine the posture of immobility and the posture and strategies of locomotion in rats with unilateral DA depletions. The rats are found to display impairments in their bad limbs (contralateral-to-lesion limbs) in adjusting posture and moving. They compensate by supporting themselves mainly on their good hindlimb, using the bad hindlimb and tail for balance and by disproportionately relying upon their good limbs to turn and to walk. Thus, their center of gravity is shifted to the good side and movement is preferentially directed toward the good side, in part to maintain equilibrium and in part to remove weight from the bad limbs so that they can enter the swing phase of the stepping cycle. It is proposed that the bad limbs may be unable to apply force to adjust posture and produce movement. These results provide a basis for predicting the movements that the animals will use in various situations and they expand the test repertoire this hemi-Parkinson model provides for studying recovery processes after loss of dopamine.

Journal

Brain ResearchElsevier

Published: May 29, 1995

References

  • A conditioned anti-parkinsonian drug effect in the hemi-parkinsonian rat
    Carey, R.J.
  • Functional Neural Transplantation
    Dunnett, S.B.; Bjorklund, A.
  • Relationship between asymmetries in striatal dopamine release and the direction of amphetamine-induced rotation during the first week following a unilateral 6-OHDA lesion of the substantia nigra
    Robinson, T.E.; Noordhoorn, M.; Chan, E.M.; Mocsary, Z.; Camp, D.; Whishaw, I.Q.

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