Carbohydrate Polymers 181 (2018) 543–550 Contents lists available at ScienceDirect Carbohydrate Polymers journal homepage: www.elsevier.com/locate/carbpol Impact of HPMC on inhibiting crystallization and improving permeability of curcumin amorphous solid dispersions ⁎ ⁎ Na Fan, Zhonggui He , Pingping Ma, Xin Wang, Chang Li, Jin Sun, Yinghua Sun, Jing Li Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, China ARTICLE I NFO ABSTRACT Keywords: The purpose of this paper was to elucidate the impacts of hydroxypropylmethyl cellulose E5 as assistant ex- Curcumin amorphous solid dispersions cipient on inhibiting crystallization and improving membrane permeability in curcumin amorphous solid dis- Inhibit crystallization persions that formulated by Eudragit E100. Intermolecular interactions formed between curcumin and polymers Improve permeability were probed using in situ Raman imaging and infrared spectroscopy. The abilities of hydroxypropylmethyl Hydrogen bonding cellulose E5 in inhibiting crystallization and improving membrane permeability were conﬁrmed by ﬂuorescence Ionic interactions spectroscopy, dynamic light scattering analysis and in vitro permeability experiment. The results demonstrated hydroxypropylmethyl cellulose E5 was signiﬁcant in maintaining the amorphous drug concentration owing to the hydrogen bond interactions formed with curcumin, rending its ability to inhibit crystallization by reducing drug droplet size. Furthermore, the addition of hydroxypropylmethyl cellulose E5 in curcumin amorphous solid
Carbohydrate Polymers – Elsevier
Published: Feb 1, 2018
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