•HBV surface proteins play a key role in viral infectivity and host immune response.•PreS/S variants may occur spontaneously or under therapeutic pressure.•PreS variability promotes cirrhosis, hepatocarcinoma and acute exacerbations.•HBsAg/anti-HBs pattern is associated with mutations and deletions in preS/S gene.
Virus Research – Elsevier
Published: Jun 15, 2017
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