Immunological and Aetiological Aspects of Macular Degeneration

Immunological and Aetiological Aspects of Macular Degeneration Aetiological and immunological aspects of AMD, a leading cause of blindness in Western countries, have been reviewed. Developmental studies suggest that anatomical features unique to the fovea result in a critical relationship between metabolic demand and blood supply at the macula, which is maintained throughout life. Recent studies show a sufficient degree of consistency in the link between smoking and both dry and wet AMD to regard it as causative. Dry AMD is considered to be the natural endstage of the disease; epidemiological and morphological studies point to choroidal vascular atrophy as the causative event and it is suggested that signals associated with acute vascular compromise lead to the development of subretinal neovascularisation. The relationship between sub-pigment epithelial deposits, including basal laminar deposit, and the pathogenesis of AMD is examined. Much of the literature is consistent with a choroidal origin for the constituents of drusen. The blood–retinal barrier preserves the physiological environment of the neural retina and limits inflammatory responses. The factors, including cytokines, adhesion molecules and the presence of resident immunocompetent cells (microglia), which determine the immune status of the retina are considered. Historical descriptions of the involvement of inflammatory cells are provided, evidence implicating inflammation in the pathogenesis of AMD involving macrophages, giant cells and microglia has been derived from observations of human and animal subretinal neovascular lesions. The role of humoral factors such as anti-retinal autoantibodies and acute phase proteins together with clinical observations has been surveyed. Taken together these data demonstrate the involvement of both cellular and humoral immunity in the pathogenesis of AMD. It remains to be determined to what degree the influence of immunity is causative or contributory in both wet and dry AMD, however, the use of anti-inflammatory agents to ameliorate the condition further indicates the existence of an inflammatory component. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Progress in Retinal and Eye Research Elsevier

Immunological and Aetiological Aspects of Macular Degeneration

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Publisher
Elsevier
Copyright
Copyright © 2001 Elsevier Science Ltd
ISSN
1350-9462
eISSN
1873-1635
D.O.I.
10.1016/S1350-9462(00)00025-2
Publisher site
See Article on Publisher Site

Abstract

Aetiological and immunological aspects of AMD, a leading cause of blindness in Western countries, have been reviewed. Developmental studies suggest that anatomical features unique to the fovea result in a critical relationship between metabolic demand and blood supply at the macula, which is maintained throughout life. Recent studies show a sufficient degree of consistency in the link between smoking and both dry and wet AMD to regard it as causative. Dry AMD is considered to be the natural endstage of the disease; epidemiological and morphological studies point to choroidal vascular atrophy as the causative event and it is suggested that signals associated with acute vascular compromise lead to the development of subretinal neovascularisation. The relationship between sub-pigment epithelial deposits, including basal laminar deposit, and the pathogenesis of AMD is examined. Much of the literature is consistent with a choroidal origin for the constituents of drusen. The blood–retinal barrier preserves the physiological environment of the neural retina and limits inflammatory responses. The factors, including cytokines, adhesion molecules and the presence of resident immunocompetent cells (microglia), which determine the immune status of the retina are considered. Historical descriptions of the involvement of inflammatory cells are provided, evidence implicating inflammation in the pathogenesis of AMD involving macrophages, giant cells and microglia has been derived from observations of human and animal subretinal neovascular lesions. The role of humoral factors such as anti-retinal autoantibodies and acute phase proteins together with clinical observations has been surveyed. Taken together these data demonstrate the involvement of both cellular and humoral immunity in the pathogenesis of AMD. It remains to be determined to what degree the influence of immunity is causative or contributory in both wet and dry AMD, however, the use of anti-inflammatory agents to ameliorate the condition further indicates the existence of an inflammatory component.

Journal

Progress in Retinal and Eye ResearchElsevier

Published: May 1, 2001

References

  • Drusen in age-related macular degeneration
    Abdelsalam, A; Del Priore, L; Zarbin, M.A
  • Oxygen distribution in the macaque retina
    Ahmed, J; Braun, R.D; Dunn, R.J; Linsenmeier, R.A
  • Spatio-temporal distribution of acidic and basic FGF indicates a role for FGF in rat lens morphogenesis
    de Iongh, R.U; McAvoy, J.W
  • Role of LFA-1, ICAM-1, VLA-4 & VCAM-1 in lymphocyte migration across retinal pigment epithelial monolayers in vitro
    Devine, I; Lightman, S.I; Greenwood, J
  • Ontogeny and cellular expression of MHC and leucocyte antigens in human retina
    Diaz-Araya, C.M; Provis, J.M; Penfold, P.L
  • Transience of astrocytes in the newborn macaque monkey retina
    Distler, C; Kirby, M.A
  • Growth factors in age-related macular degeneration
    Frank, R.N
  • Age-related macular degeneration and choroidal neovascularization
    Freund, K.B; Yannuzzi, L.A; Sorenson, J.A
  • Senile macular degeneration
    Friedman, A.H; Pokorny, K.S; Suhan, J.P; Kornzweig, A.L
  • Progress in measurement of ocular blood flow and relevance to our understanding of glaucoma and age-related macular degeneration
    Harris, A; Chung, H.S; Ciulla, T.A; Kagemann, L
  • Corticosteroids inhibit the expression of the vascular endothelial growth factor gene in human vascular smooth muscle cells
    Nauck, M; Karakiulakis, G; Perruchoud, A.P; Papakonstantinou, E; Roth, M
  • Longitudinal analysis of soluble intercellular adhesion molecule 1 in retinal vasculitis
    Palmer, H.E; Zaman, A.G; Ellis, B.A; Stanford, M.R; Graham, E.M; Wallace, G.R
  • Triamcinolone acetonide modulates the permeability and intercellular adhesion molecule-1 (ICAM-1) expression of the ECV304 cell line
    Penfold, P.L; Wen, L; Madigan, M.C; Gillies, M.C; King, N.J.C; Provis, J.M
  • Human retinal microglia
    Provis, J.M; Penfold, P.L; Edwards, A.J; van, D.D
  • Development of the Human Retina
    Provis, J.M; van Driel, D; Billson, F.A.B; Russell, P
  • Immunoregulatory mechanisms of the eye
    Streilein, J.W; Wilbanks, G.A; Cousins, S.W
  • Growth factors and their receptors in the retina and pigment epithelium
    Tanihara, H; Inatani, M; Honda, Y

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