Forensic Science International 273 (2017) 71–79 Contents lists available at ScienceDirect Forensic Science International journal homepage: www.elsevier.com/locat e/f orsciint Immunohistochemical methods as an aid in estimating the time since death Jan Ortmann, Elke Doberentz, Burkhard Madea* Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany A R T I C L E I N F O A B S T R A C T Article history: For the estimation of time since death in the early postmortem interval, a large repertoire of valid Received 27 December 2016 Received in revised form 11 January 2017 methods is available. With increasing time since death the estimation of the postmortem interval Accepted 3 February 2017 becomes more imprecise and unreliable because validated methods are missing. Wehner et al. developed Available online 14 February 2017 a method to estimate the time since death using immunohistochemical staining. Proteins undergo degradation after death and this reduces their stainability. Previous studies have explored the Keywords: development of a method to estimate the time since death using immunohistochemical staining. A Time of death systematic analysis (Wehner et al., 1999–2002) demonstrated that calcitonin can still be stained 4 days, Immunohistochemistry thyreoglobulin 5 days, glucagon 6
Forensic Science International – Elsevier
Published: Apr 1, 2017
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