Immunohistochemical methods as an aid in estimating the time since death

Immunohistochemical methods as an aid in estimating the time since death Forensic Science International 273 (2017) 71–79 Contents lists available at ScienceDirect Forensic Science International journal homepage: www.elsevier.com/locat e/f orsciint Immunohistochemical methods as an aid in estimating the time since death Jan Ortmann, Elke Doberentz, Burkhard Madea* Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany A R T I C L E I N F O A B S T R A C T Article history: For the estimation of time since death in the early postmortem interval, a large repertoire of valid Received 27 December 2016 Received in revised form 11 January 2017 methods is available. With increasing time since death the estimation of the postmortem interval Accepted 3 February 2017 becomes more imprecise and unreliable because validated methods are missing. Wehner et al. developed Available online 14 February 2017 a method to estimate the time since death using immunohistochemical staining. Proteins undergo degradation after death and this reduces their stainability. Previous studies have explored the Keywords: development of a method to estimate the time since death using immunohistochemical staining. A Time of death systematic analysis (Wehner et al., 1999–2002) demonstrated that calcitonin can still be stained 4 days, Immunohistochemistry thyreoglobulin 5 days, glucagon 6 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Forensic Science International Elsevier

Immunohistochemical methods as an aid in estimating the time since death

Loading next page...
 
/lp/elsevier/immunohistochemical-methods-as-an-aid-in-estimating-the-time-since-UNHrvqolo5
Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0379-0738
D.O.I.
10.1016/j.forsciint.2017.02.004
Publisher site
See Article on Publisher Site

Abstract

Forensic Science International 273 (2017) 71–79 Contents lists available at ScienceDirect Forensic Science International journal homepage: www.elsevier.com/locat e/f orsciint Immunohistochemical methods as an aid in estimating the time since death Jan Ortmann, Elke Doberentz, Burkhard Madea* Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany A R T I C L E I N F O A B S T R A C T Article history: For the estimation of time since death in the early postmortem interval, a large repertoire of valid Received 27 December 2016 Received in revised form 11 January 2017 methods is available. With increasing time since death the estimation of the postmortem interval Accepted 3 February 2017 becomes more imprecise and unreliable because validated methods are missing. Wehner et al. developed Available online 14 February 2017 a method to estimate the time since death using immunohistochemical staining. Proteins undergo degradation after death and this reduces their stainability. Previous studies have explored the Keywords: development of a method to estimate the time since death using immunohistochemical staining. A Time of death systematic analysis (Wehner et al., 1999–2002) demonstrated that calcitonin can still be stained 4 days, Immunohistochemistry thyreoglobulin 5 days, glucagon 6

Journal

Forensic Science InternationalElsevier

Published: Apr 1, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off