Immunohistochemical methods as an aid in estimating the time since death

Immunohistochemical methods as an aid in estimating the time since death Forensic Science International 273 (2017) 71–79 Contents lists available at ScienceDirect Forensic Science International journal homepage: www.elsevier.com/locat e/f orsciint Immunohistochemical methods as an aid in estimating the time since death Jan Ortmann, Elke Doberentz, Burkhard Madea* Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany A R T I C L E I N F O A B S T R A C T Article history: For the estimation of time since death in the early postmortem interval, a large repertoire of valid Received 27 December 2016 Received in revised form 11 January 2017 methods is available. With increasing time since death the estimation of the postmortem interval Accepted 3 February 2017 becomes more imprecise and unreliable because validated methods are missing. Wehner et al. developed Available online 14 February 2017 a method to estimate the time since death using immunohistochemical staining. Proteins undergo degradation after death and this reduces their stainability. Previous studies have explored the Keywords: development of a method to estimate the time since death using immunohistochemical staining. A Time of death systematic analysis (Wehner et al., 1999–2002) demonstrated that calcitonin can still be stained 4 days, Immunohistochemistry thyreoglobulin 5 days, glucagon 6 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Forensic Science International Elsevier

Immunohistochemical methods as an aid in estimating the time since death

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0379-0738
D.O.I.
10.1016/j.forsciint.2017.02.004
Publisher site
See Article on Publisher Site

Abstract

Forensic Science International 273 (2017) 71–79 Contents lists available at ScienceDirect Forensic Science International journal homepage: www.elsevier.com/locat e/f orsciint Immunohistochemical methods as an aid in estimating the time since death Jan Ortmann, Elke Doberentz, Burkhard Madea* Institute of Forensic Medicine, University of Bonn, Stiftsplatz 12, 53111 Bonn, Germany A R T I C L E I N F O A B S T R A C T Article history: For the estimation of time since death in the early postmortem interval, a large repertoire of valid Received 27 December 2016 Received in revised form 11 January 2017 methods is available. With increasing time since death the estimation of the postmortem interval Accepted 3 February 2017 becomes more imprecise and unreliable because validated methods are missing. Wehner et al. developed Available online 14 February 2017 a method to estimate the time since death using immunohistochemical staining. Proteins undergo degradation after death and this reduces their stainability. Previous studies have explored the Keywords: development of a method to estimate the time since death using immunohistochemical staining. A Time of death systematic analysis (Wehner et al., 1999–2002) demonstrated that calcitonin can still be stained 4 days, Immunohistochemistry thyreoglobulin 5 days, glucagon 6

Journal

Forensic Science InternationalElsevier

Published: Apr 1, 2017

References

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