Immunohistochemical detection of vimentin in pancreatic islet β- and α-cells of macrosomic infants of diabetic and nondiabetic mothers

Immunohistochemical detection of vimentin in pancreatic islet β- and α-cells of macrosomic... BackgroundExpression of the intermediate filament protein vimentin has been recently observed in the pancreatic islet β- and α-cells of humans with type 2 diabetes mellitus. It was suggested that the presence of vimentin in endocrine cells may indicate islet tissue renewal, or potentially represent the dedifferentiation of endocrine cells, which could contribute to the onset of type 2 diabetes or islet cell dysfunction. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Early Human Development Elsevier

Immunohistochemical detection of vimentin in pancreatic islet β- and α-cells of macrosomic infants of diabetic and nondiabetic mothers

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Publisher
Elsevier
Copyright
Copyright © 2017 Elsevier B.V.
ISSN
0378-3782
D.O.I.
10.1016/j.earlhumdev.2017.12.009
Publisher site
See Article on Publisher Site

Abstract

BackgroundExpression of the intermediate filament protein vimentin has been recently observed in the pancreatic islet β- and α-cells of humans with type 2 diabetes mellitus. It was suggested that the presence of vimentin in endocrine cells may indicate islet tissue renewal, or potentially represent the dedifferentiation of endocrine cells, which could contribute to the onset of type 2 diabetes or islet cell dysfunction.

Journal

Early Human DevelopmentElsevier

Published: Feb 1, 2018

References

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