Immune modulatory properties of 6-gingerol and resveratrol in Atlantic salmon macrophages

Immune modulatory properties of 6-gingerol and resveratrol in Atlantic salmon macrophages •Both 6-gingerol and resveratrol have immune modifying effects in Atlantic salmon head kidney macrophages in vitro.•Pre-treatment with 6-gingerol and resveratrol attenuated the respiratory burst response in Atlantic salmon macrophages.•Both 6-gingerol and resveratrol suppress anti-bacterial and inflammation-relevant gene induction following LPS stimulation.•Pre-treatment with 6-gingerol and resveratrol decreased the number of macrophages able to phagocytize fluorescent beads.•Pre-treatment with 6-gingerol appeared to have a more pronounced anti-inflammatory effect than resveratrol. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Immunology Elsevier

Immune modulatory properties of 6-gingerol and resveratrol in Atlantic salmon macrophages

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Publisher
Pergamon
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
0161-5890
D.O.I.
10.1016/j.molimm.2018.01.004
Publisher site
See Article on Publisher Site

Abstract

•Both 6-gingerol and resveratrol have immune modifying effects in Atlantic salmon head kidney macrophages in vitro.•Pre-treatment with 6-gingerol and resveratrol attenuated the respiratory burst response in Atlantic salmon macrophages.•Both 6-gingerol and resveratrol suppress anti-bacterial and inflammation-relevant gene induction following LPS stimulation.•Pre-treatment with 6-gingerol and resveratrol decreased the number of macrophages able to phagocytize fluorescent beads.•Pre-treatment with 6-gingerol appeared to have a more pronounced anti-inflammatory effect than resveratrol.

Journal

Molecular ImmunologyElsevier

Published: Mar 1, 2018

References

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