The effects of the anti-inflammatory cytokine, IL-10, on brain injury following permanent focal ischemia were determined. Rats subjected to occlusion of the right middle cerebral artery (MCAO) were administered IL-10 (1 μ g) centrally into the lateral ventricle 30 min and 3 h post MCAO or systemically into the tail vein (5 or 15 μ g/h) starting 30 min post MCAO for 3 h. Brains were removed 24 h later and infarct size was measured. IL-10 administered centrally significantly ( P <0.01) reduced infarct size by 20.7%±6.0 compared to vehicle. Systemic IL-10 administration at 5 and 15 μ g/h significantly ( P <0.05) decreased infarct size (40.3%±14.0 and 30.7%±13.7, respectively). These studies indicate that an anti-inflammatory therapeutic approach using IL-10 can provide neuroprotection in ischemic stroke.
Neuroscience Letters – Elsevier
Published: Jul 31, 1998
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