Identification of Pore-forming Subunit of P-type Calcium Channels: an Antisense Study on Rat Cerebellar Purkinje Cells in Culture

Identification of Pore-forming Subunit of P-type Calcium Channels: an Antisense Study on Rat... Treatment of cerebellar neurones in culture with an antisense oligonucleotide (ODN) against α 1A , reduced the whole-cell P-type calcium channel current relative to mismatch ODN treated controls ( p < 0.001). Therefore, AgaIVA (50 nM) reduced whole-cell calcium current in mismatch and antisense treated cells by 70 ± 4 and 19 ± 3%, respectively. © 1997 Elsevier Science Ltd. All rights reserved. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuropharmacology Elsevier

Identification of Pore-forming Subunit of P-type Calcium Channels: an Antisense Study on Rat Cerebellar Purkinje Cells in Culture

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Publisher
Elsevier
Copyright
Copyright © 1997 Elsevier Science Ltd
ISSN
0028-3908
eISSN
1873-7064
D.O.I.
10.1016/S0028-3908(97)00046-4
Publisher site
See Article on Publisher Site

Abstract

Treatment of cerebellar neurones in culture with an antisense oligonucleotide (ODN) against α 1A , reduced the whole-cell P-type calcium channel current relative to mismatch ODN treated controls ( p < 0.001). Therefore, AgaIVA (50 nM) reduced whole-cell calcium current in mismatch and antisense treated cells by 70 ± 4 and 19 ± 3%, respectively. © 1997 Elsevier Science Ltd. All rights reserved.

Journal

NeuropharmacologyElsevier

Published: Mar 1, 1997

References

  • Structure and function of voltage-gated ion channels
    Catterall, W.A

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