Treatment of cerebellar neurones in culture with an antisense oligonucleotide (ODN) against α 1A , reduced the whole-cell P-type calcium channel current relative to mismatch ODN treated controls ( p < 0.001). Therefore, AgaIVA (50 nM) reduced whole-cell calcium current in mismatch and antisense treated cells by 70 ± 4 and 19 ± 3%, respectively. © 1997 Elsevier Science Ltd. All rights reserved.
Neuropharmacology – Elsevier
Published: Mar 1, 1997
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