Identification of epistatic mutations and insights into the evolution of the influenza virus using a mass-based protein phylogenetic approach

Identification of epistatic mutations and insights into the evolution of the influenza virus... Molecular Phylogenetics and Evolution 121 (2018) 132–138 Contents lists available at ScienceDirect Molecular Phylogenetics and Evolution journal homepage: www.elsevier.com/locate/ympev Identification of epistatic mutations and insights into the evolution of the influenza virus using a mass-based protein phylogenetic approach Elma H. Akand, Kevin.M. Downard Infectious Disease Responses Laboratory, University of New South Wales, Sydney, Australia ARTICLE I NFO ABSTRACT Keywords: A mass-based protein phylogenetic approach developed in this laboratory has been applied to study mutation Evolution trends and identify consecutive or near-consecutive mutations typically associated with positive epistasis. While Phylogenetics epistasis is thought to occur commonly during the evolution of viruses, the extent of epistasis in influenza, and its Mutation role in the evolution of immune escape and drug resistant mutants, remains to be systematically investigated. Epistasis Here putative epistatic mutations within H3 hemagglutinin in type A influenza are identified where leading Influenza virus parent mutations were found to predominate within reported antigenic sites of the protein. Frequent subsequent Mass spectrometry mutations resided exclusively in different antigenic regions, providing the virus with a possible immune escape mechanism, or at other remote sites that drive beneficial protein structural and functional change. The results also enable a “small steps” evolutionary model to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Phylogenetics and Evolution Elsevier

Identification of epistatic mutations and insights into the evolution of the influenza virus using a mass-based protein phylogenetic approach

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Inc.
ISSN
1055-7903
eISSN
1095-9513
D.O.I.
10.1016/j.ympev.2018.01.009
Publisher site
See Article on Publisher Site

Abstract

Molecular Phylogenetics and Evolution 121 (2018) 132–138 Contents lists available at ScienceDirect Molecular Phylogenetics and Evolution journal homepage: www.elsevier.com/locate/ympev Identification of epistatic mutations and insights into the evolution of the influenza virus using a mass-based protein phylogenetic approach Elma H. Akand, Kevin.M. Downard Infectious Disease Responses Laboratory, University of New South Wales, Sydney, Australia ARTICLE I NFO ABSTRACT Keywords: A mass-based protein phylogenetic approach developed in this laboratory has been applied to study mutation Evolution trends and identify consecutive or near-consecutive mutations typically associated with positive epistasis. While Phylogenetics epistasis is thought to occur commonly during the evolution of viruses, the extent of epistasis in influenza, and its Mutation role in the evolution of immune escape and drug resistant mutants, remains to be systematically investigated. Epistasis Here putative epistatic mutations within H3 hemagglutinin in type A influenza are identified where leading Influenza virus parent mutations were found to predominate within reported antigenic sites of the protein. Frequent subsequent Mass spectrometry mutations resided exclusively in different antigenic regions, providing the virus with a possible immune escape mechanism, or at other remote sites that drive beneficial protein structural and functional change. The results also enable a “small steps” evolutionary model to

Journal

Molecular Phylogenetics and EvolutionElsevier

Published: Apr 1, 2018

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