Molecular Phylogenetics and Evolution 121 (2018) 132–138 Contents lists available at ScienceDirect Molecular Phylogenetics and Evolution journal homepage: www.elsevier.com/locate/ympev Identiﬁcation of epistatic mutations and insights into the evolution of the inﬂuenza virus using a mass-based protein phylogenetic approach Elma H. Akand, Kevin.M. Downard Infectious Disease Responses Laboratory, University of New South Wales, Sydney, Australia ARTICLE I NFO ABSTRACT Keywords: A mass-based protein phylogenetic approach developed in this laboratory has been applied to study mutation Evolution trends and identify consecutive or near-consecutive mutations typically associated with positive epistasis. While Phylogenetics epistasis is thought to occur commonly during the evolution of viruses, the extent of epistasis in inﬂuenza, and its Mutation role in the evolution of immune escape and drug resistant mutants, remains to be systematically investigated. Epistasis Here putative epistatic mutations within H3 hemagglutinin in type A inﬂuenza are identiﬁed where leading Inﬂuenza virus parent mutations were found to predominate within reported antigenic sites of the protein. Frequent subsequent Mass spectrometry mutations resided exclusively in diﬀerent antigenic regions, providing the virus with a possible immune escape mechanism, or at other remote sites that drive beneﬁcial protein structural and functional change. The results also enable a “small steps” evolutionary model to
Molecular Phylogenetics and Evolution – Elsevier
Published: Apr 1, 2018
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