Jung Y. Hahr
Childrens Hospital of Wisconsin, Milwaukee, WI, United States
Received 4 April 2013
Accepted 23 April 2013
Autism as we know it, is caused iatrogenically and occurs reportedly one in 88 live birth . Now national
survey pegs autism prevalence one in 50 school-age children and the incidence is rising much fast in
The author is hypothesizing idiopathic autism is caused by feeding of infant formula. Majorities of for-
mula in the world are milk based and the molecular weight of the cow’s milk is much higher than that of
human breast milk. These increased solutes contributes to increased osmolality of the environment of the
newborn infant, is directly affecting hemodynamics of normal homeostasis of the developing human
brain cells. Formula makers fortiﬁed new substances in the process of formula making whenever they
found previous unknown substances in the breast milk, for past several decades. When those solid sub-
stances were added in the process of formula making to make 20 cal/oz of infant formula, this resulted
displacing free water in the formula. When new substances were added, same amount of free water
has to be displaced from the formula. That is why we are seeing more autism in recent years, compared
to previous several decades.
Ó 2013 Elsevier Ltd. All rights reserved.
Rising incidence of Autism in today’s society is rather alarming
and when particularly it is induced iatrogenically. It is induced
by feeding cow’s milk formula to our infant that increased
extracellular osmolality and that injured developing brain cells of
infants. The author is intended to elucidate physiologic changes
that take place in the neuronal cells of the brain when infants were
fed cow’s milk formula.
Human baby fed strictly breast milk alone has plasma osmolal-
ity of 284.3 mosm/kg , on the other hand, babies fed cow’s milk
formula, their plasma osmolality is 293.9 mosm/kg and those in-
fants who fed solid foods as well as formula are 297.1 mosm .
Nelson’s textbook of Pediatrics report serum osmolality ranges
275 mosm/kg in child, 295 mosm/kg in adult . Cells of the devel-
oping brain of the breast fed infant are equal in intracellular and
extracellular osmolality at 284.3 mosm , the cells of developing
brain of formula fed infant have subjected signiﬁcant increase of
extracellular osmolality at 293.9 mosm/kg. These sudden increase
of extracellular osmolality causes increased osmolality of intracel-
lular environment of developing brain cells. Developing brain cells
lose intracellular water by osmosis.
It appears that all living organisms start rather with large
amount of free water in the body, this gradually changes less water
as embryos eventually matures to full term. In human newborn in-
fant, they have 78% of their body weight is water at the time of
birth. This changes to gradually to 70% at the end of ﬁrst year.
These numbers continuously change throughout our lives and we
have approximately 60% of our body weight is water at age 60 year.
We can look ourselves, we started our lives with water, more than
99% of bodies weight and at the time of our natural death, our
bodies contain far less water than 60% of our body weight. Water
is largest composition of our body.
Protein in the human breast milk and that of cow’s milk are fun-
damentally different. Proteins of the human milk are much more
suitable for human consumption and they are easily digestible
than that of cow’s milk, even though they are much less quantity.
Increased solutes in the cow’s milk is due to largely whey protein
which contribute to increased extracellular osmolality when it is
consumed. Even though formula makers have reduced amount of
whey protein in the formula, but still large portion of the whey
protein is still left in the formula. This large amount of whey pro-
tein in the formula works like space occupying agent. This in turn
reduces available free water in the formula, because formula is
made to 20 cal/oz. Any substances added to make formula, same
amount free water has to be displaced from formula to make
Osmolality of Infant fed human breast milk has equal intracel-
lular and extracellular osmolality at 284.3 mosm/kg . On the
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Medical Hypotheses 81 (2013) 251–252
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