•The hypotensive effect of Alamandine at the CVLM involves different mechanisms.•There is difference in the effects of alamandine at CVLM of normotensive and 2K1C hypertensive rats.•CVLM hypotensive effect induced by alamandine was blocked by D-Pro7-Ang-(1–7) and PD antagonists.•Alamandine produced U-shapped effect on blood pressure in the CVLM of 2K1C rats.
Peptides – Elsevier
Published: Oct 1, 2017
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