Hypoglossal nerve stimulation in a pre-clinical anesthetized rabbit model relevant to OSA

Hypoglossal nerve stimulation in a pre-clinical anesthetized rabbit model relevant to OSA •An anesthetized rabbit was deployed to examine effectiveness of CNXII nerve stimulation to relieve oropharyngeal obstruction.•The effect of stimulation was pronounced on the medial branch than the trunk of the hypoglossal nerve.•One predominant effect of a reduction in airflow resistance was observed to be the size and shape of the retropalatal area.•The model recapitulates some features of human obstructive sleep apnea and may serve as a platform to improved neurostimulation technology. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Respiratory Physiology & Neurobiology Elsevier

Hypoglossal nerve stimulation in a pre-clinical anesthetized rabbit model relevant to OSA

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Publisher
Elsevier
Copyright
Copyright © 2018 Elsevier Ltd
ISSN
1569-9048
eISSN
1878-1519
D.O.I.
10.1016/j.resp.2018.01.015
Publisher site
See Article on Publisher Site

Abstract

•An anesthetized rabbit was deployed to examine effectiveness of CNXII nerve stimulation to relieve oropharyngeal obstruction.•The effect of stimulation was pronounced on the medial branch than the trunk of the hypoglossal nerve.•One predominant effect of a reduction in airflow resistance was observed to be the size and shape of the retropalatal area.•The model recapitulates some features of human obstructive sleep apnea and may serve as a platform to improved neurostimulation technology.

Journal

Respiratory Physiology & NeurobiologyElsevier

Published: Apr 1, 2018

References

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