Acta Biomaterialia 71 (2018) 235–246 Contents lists available at ScienceDirect Acta Biomaterialia journal homepage: www.elsevier.com/locate/actabiomat Full length article Human iPSC-derived mesenchymal stem cells encapsulated in PEGDA hydrogels mature into valve interstitial-like cells a a b,c b,c a,b,c a,b,⇑ Aline L.Y. Nachlas , Siyi Li , Rajneesh Jha , Monalisa Singh , Chunhui Xu , Michael E. Davis Wallace H Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA Children’s Heart Research & Outcomes (HeRO) Center, Children’s Healthcare of Atlanta & Emory University, Atlanta, GA, USA Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, USA article i nfo abstract Article history: Despite recent advances in tissue engineered heart valves (TEHV), a major challenge is identifying a cell Received 4 October 2017 source for seeding TEHV scaffolds. Native heart valves are durable because valve interstitial cells (VICs) Received in revised form 6 February 2018 maintain tissue homeostasis by synthesizing and remodeling the extracellular matrix. This study demon- Accepted 22 February 2018 strates that induced pluripotent stem cells (iPSC)-derived mesenchymal stem cells (iMSCs) can be Available online 2 March 2018 derived from iPSCs using a feeder-free protocol and then further matured into
Acta Biomaterialia – Elsevier
Published: Apr 15, 2018
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