Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport

Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental... •IgG1 modified to reduce cytotoxicity (G1Δnab) has impaired FcRn-mediated function.•G1Δnab variants bind FcRn in a pH-dependent manner but with altered kinetics.•G1Δnab variants are transported to a lesser degree across polarized cells and placenta.•Data collectively point to residues originating from IgG2 affecting IgG transport. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Immunology Elsevier

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Publisher
Elsevier
Copyright
Copyright © 2018 The Authors
ISSN
0161-5890
D.O.I.
10.1016/j.molimm.2018.01.006
Publisher site
See Article on Publisher Site

Abstract

•IgG1 modified to reduce cytotoxicity (G1Δnab) has impaired FcRn-mediated function.•G1Δnab variants bind FcRn in a pH-dependent manner but with altered kinetics.•G1Δnab variants are transported to a lesser degree across polarized cells and placenta.•Data collectively point to residues originating from IgG2 affecting IgG transport.

Journal

Molecular ImmunologyElsevier

Published: Mar 1, 2018

References

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