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of applications. By wisely choosing functional monomers with interaction with a certain part of the template, and special cross-linkers to enhance the imprinting effect , the resulting MIP could be expected ...
with the functional monomers . The NIP is useful in demonstrating how the 3D cavity formed by the template molecule is crucial in creating a specific binding site with the functional monomer . Further, the NIP can ...
performance liquid chromatography with diode-array detection (UHPLC-DAD). After optimization, MIPs were synthesized using cephazolin as the template, methacrylic acid as the functional monomer , triethylenglycol ...
this non-random 3D organization only reflects or indeed contributes—and how —to the regulation of genome function remain to be elucidated. The observation in many species that 3D domains correlate strongly ...
phosphorylated) state and (6 − m) monomers are in U (unphosphorylated) state (Fig 5A) and then calculate the apparent binding rate by fitting the curves in Fig 5A to a single exponential function (Fig 5C ...
unsolved mysteries. How do these enzymes work, molecularly ? Do they have superficial catalytic sites? How do they act on the sturdy plastic structure? What is their function in nature? Do both enzymes ...
after IC inoculation. https://doi.org/10.1371/journal.ppat.1004290.t001 We next performed homology modeling to gain insight into the structural basis of E-244 function . The 3D model of the E monomer ...
monomer exchange and the discovery that not all actin filaments are capped [17–19]. Capping is provided by the two capping molecules adducin (for the fast-growing barbed end) and tropomodulin (for the slow ...
of actionable mutational variants, and software and tools for variant annotation. They also assemble databases for predicting the impact on protein function . They detail how to exploit this collection, either ...
to be arranged as a homodimer that can fulfill the function of the yPrp42/yPrp39 heterodimer. Based on our structure, we investigated the effect of point mutations that interfere with dimerization and we show ...
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