Horizontal cells of the rat retina are resistant to degenerative processes induced by ischemia-reperfusion

Horizontal cells of the rat retina are resistant to degenerative processes induced by... The fate of calbindin D 28k (calbindin)-labeled horizontal cells in the ischemic rat retina induced by increasing intraocular pressure was investigated by immunocytochemistry using an antiserum against calbindin. In the normal retina, strong calbindin-like immunoreactivity was seen in the horizontal cells, and the density of the labelled horizontal cells was 815.3±15.2 per mm 2 . The thickness of the treated retina became progressively thinner with increasing reperfusion time after the ischemic insult due to a loss of retinal cells in the inner and outer nuclear layers. However, the densities of the horizontal cells per mm 2 were 814.0±26.4 at 1 week, 813.3±20.8 at 2 weeks, and 812.6±11.5 at 4 weeks, indicating that horizontal cells did not degenerate during experimental periods. Thus, calbindin may have a protective role for horizontal cells to ischemic insult by its ability to buffer calcium influx in the rat retina. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroscience Letters Elsevier

Horizontal cells of the rat retina are resistant to degenerative processes induced by ischemia-reperfusion

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Publisher
Elsevier
Copyright
Copyright © 1999 Elsevier Science Ireland Ltd
ISSN
0304-3940
D.O.I.
10.1016/S0304-3940(98)00973-2
Publisher site
See Article on Publisher Site

Abstract

The fate of calbindin D 28k (calbindin)-labeled horizontal cells in the ischemic rat retina induced by increasing intraocular pressure was investigated by immunocytochemistry using an antiserum against calbindin. In the normal retina, strong calbindin-like immunoreactivity was seen in the horizontal cells, and the density of the labelled horizontal cells was 815.3±15.2 per mm 2 . The thickness of the treated retina became progressively thinner with increasing reperfusion time after the ischemic insult due to a loss of retinal cells in the inner and outer nuclear layers. However, the densities of the horizontal cells per mm 2 were 814.0±26.4 at 1 week, 813.3±20.8 at 2 weeks, and 812.6±11.5 at 4 weeks, indicating that horizontal cells did not degenerate during experimental periods. Thus, calbindin may have a protective role for horizontal cells to ischemic insult by its ability to buffer calcium influx in the rat retina.

Journal

Neuroscience LettersElsevier

Published: Jan 29, 1999

References

  • Expression of NMDA and high-affinity kainate receptor subunit mRNAs in the adult rat retina
    Brandstätter, J.H.; Hartveit, E.; Sassoè-Pognetto, M.; Wässle, H.
  • Differential vulnerability of neurochemically identified subpopulations of retinal neurons in a monkey model of glaucoma
    Vickers, J.C.; Schumer, R.A.; Podos, S.M.; Wang, R.F.; Riederer, B.M.; Morrison, J.H.
  • Calcium binding proteins in the retina of a calbindin-null mutant mouse
    Wãssle, H.; Peichl, L.; Airaksinen, M.S.; Meyer, M.

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