Case Report HIV-related Refractory Hodgkin Lymphoma: A Case Report of Complete Response to Nivolumab 1,2 1,3 4,5 2,6 Elaine Chang, Gustavo Rivero, Niraj R. Patel, Elizabeth Y. Chiao, 8,9 1 7 1,3 Syeling Lai, Kelash Bajaj, John E. Mbue, Sarvari V. Yellapragada Clinical Practice Points We present a case of a veteran with well-controlled unique biology, particularly the near-universal asso- human immunodeﬁciency virus (HIV) infection and ciation with Epstein-Barr virus, regardless of histology, primary refractory classical Hodgkin lymphoma (HL) suggests that immunotherapy may have an important who, after multiple prior lines of therapy, received role in the management of this disease. nivolumab with a complete response. He also devel- Most clinical trials highlighting checkpoint inhibitors oped autoimmune diabetes mellitus after 6 months of have excluded HIV-infected patients. More prospec- nivolumab. tive data is clearly needed to delineate the risks and HIV-associated HL is currently treated under the same beneﬁts of immunotherapy in this population with algorithm as HL in the general population, but its increased autoimmunity at baseline. Clinical Lymphoma, Myeloma & Leukemia, Vol. 18, No. 2, e143-6 ª 2017 Elsevier Inc. All rights reserved. Keywords: Anti-PD-1, Autoimmune diabetes, Human immunodeﬁciency virus, Immune checkpoint inhibitor, Immune-related adverse event
Clinical Lymphoma Myeloma and Leukemia – Elsevier
Published: Feb 1, 2018
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