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Histologic diagnosis of inflammatory skin diseases—An algorithmic method based on pattern analysis. Second edition

BOOK REVIEW malignant melanoma remains highly unusual. Indeed, LCH is classically reported in association with other subtypes of Hodgkin's disease, but to our knowledge has never been described with N-LPHD. It has been previously described only once in lymph nodes draining the cutaneous site of a malignant melanoma .4 The pathogeny of LCH associated with neoplastic disorders is still unclear, and in our case, its association with two i n d e p e n d e n t but neighboring tumors raises some interesting questions. LCs belong to the dendritic cell (DC) lineage which is specialized in the processing and the presentation of antigens to T cells. 1 They may be recruited in several skin disorders including inflammatory diseases and tumors such as malignant melanoma. :,4 It is tempting to speculate that, in our case, these cells might have migrated from the melanoma site (where tumor antigens are shedded and processed) via the afferent lymphati£s to the T-dependent areas of the axil!ary lymph nodes (where antigens are presented to T cells) and accumulated there with the help of cytokines locally secreted by the adjacent N-LPHD neoplastic process. There is evidence that during their migration, DCs undergo a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Human Pathology Elsevier

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