Hippocampal and septal injections of nicotine and 8-OH-DPAT distinguish among different animal tests of anxiety

Hippocampal and septal injections of nicotine and 8-OH-DPAT distinguish among different animal... 1. 1. Different animal tests model different anxiety disorders. Thus, the social interaction test is a model of generalised anxiety disorder, plus-maze Trial 1 models elements of panic disorder and Trial 2 in the elevated plus-maze is a model of specific phobia. 2. 2. Studies of the neuroanatomical and neurochemical pathways controlling behaviour in these different tests provides information on the neurobiological mechanisms modulating anxiety disorders. 3. 3. In the social interaction test, nicotine and 8-OH-DPAT had anxiogenic effects when injected into the dorsal hippocampus or the lateral septum. 4. 4. These ligands were without effect on Trial 1 in the plus-maze when injected into the dorsal hippocampus, but had anxiogenic effects when injected into the lateral septum. 5. 5. On Trial 2 in the elevated plus-maze, nicotine had an anxiolytic effect, but 8-OH-DPAT had an aaxiogenic effect when injected into the dorsal hippocampus. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Progress in Neuro-Psychopharmacology & Biological Psychiatry Elsevier

Hippocampal and septal injections of nicotine and 8-OH-DPAT distinguish among different animal tests of anxiety

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Publisher
Elsevier
Copyright
Copyright © 2000 Elsevier Ltd
ISSN
0278-5846
eISSN
1878-4216
DOI
10.1016/S0278-5846(00)00129-9
Publisher site
See Article on Publisher Site

Abstract

1. 1. Different animal tests model different anxiety disorders. Thus, the social interaction test is a model of generalised anxiety disorder, plus-maze Trial 1 models elements of panic disorder and Trial 2 in the elevated plus-maze is a model of specific phobia. 2. 2. Studies of the neuroanatomical and neurochemical pathways controlling behaviour in these different tests provides information on the neurobiological mechanisms modulating anxiety disorders. 3. 3. In the social interaction test, nicotine and 8-OH-DPAT had anxiogenic effects when injected into the dorsal hippocampus or the lateral septum. 4. 4. These ligands were without effect on Trial 1 in the plus-maze when injected into the dorsal hippocampus, but had anxiogenic effects when injected into the lateral septum. 5. 5. On Trial 2 in the elevated plus-maze, nicotine had an anxiolytic effect, but 8-OH-DPAT had an aaxiogenic effect when injected into the dorsal hippocampus.

Journal

Progress in Neuro-Psychopharmacology & Biological PsychiatryElsevier

Published: Oct 1, 2000

References

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